[HTML][HTML] Blood-brain barrier leakage in Alzheimer's disease: From discovery to clinical relevance

G Nehra, B Bauer, AMS Hartz - Pharmacology & therapeutics, 2022 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia. AD brain pathology starts
decades before the onset of clinical symptoms. One early pathological hallmark is blood …

[HTML][HTML] Unraveling the impact of Omega-3 polyunsaturated fatty acids on blood-brain barrier (BBB) integrity and glymphatic function

J Wen, SK Satyanarayanan, A Li, L Yan, Z Zhao… - Brain, Behavior, and …, 2024 - Elsevier
Alzheimer's disease (AD) and other forms of dementia represent major public health
challenges but effective therapeutic options are limited. Pathological brain aging is …

Gut microbiome-targeted therapies for Alzheimer's disease

T Zhang, G Gao, LY Kwok, Z Sun - Gut microbes, 2023 - Taylor & Francis
The advent of highthroughput 'omics' technologies has improved our knowledge of gut
microbiome in human health and disease, including Alzheimer's disease (AD), a …

Dietary and supplemental long-chain omega-3 fatty acids as moderators of cognitive impairment and Alzheimer's disease

AHR Wood, HF Chappell, MA Zulyniak - European journal of nutrition, 2022 - Springer
Purpose There is an ever-growing body of literature examining the relationship between
dietary omega-3 polyunsaturated fatty acids (ω3 PUFAs) and cerebral structure and function …

[HTML][HTML] Gut microbiota and its metabolites: bridge of dietary nutrients and Alzheimer's disease

G Zhu, J Zhao, H Zhang, G Wang, W Chen - Advances in Nutrition, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
cognitive impairment and neuroinflammation. Recent research has revealed the crucial role …

Dietary regulation of gut-brain axis in Alzheimer's disease: Importance of microbiota metabolites

DM Frausto, CB Forsyth, A Keshavarzian… - Frontiers in …, 2021 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disease that impacts 45 million people
worldwide and is ranked as the 6th top cause of death among all adults by the Centers for …

The role of polyunsaturated fatty acids in neuronal signaling in depression and cognitive processes

K Stachowicz - Archives of Biochemistry and Biophysics, 2023 - Elsevier
This study aimed to evaluate research findings on the role of polyunsaturated fatty acids
(PUFAs) in neuronal signaling. Polyunsaturated fatty acids (PUFAs) are the building blocks …

Cell death via lipid peroxidation and protein aggregation diseases

K Iuchi, T Takai, H Hisatomi - Biology, 2021 - mdpi.com
Simple Summary It is essential for cellular homeostasis that biomolecules, such as DNA,
proteins, and lipids, function properly. Disturbance of redox homeostasis produces aberrant …

Microbiota–gut–brain axis in health and neurological disease: Interactions between gut microbiota and the nervous system

Y He, K Wang, N Su, C Yuan, N Zhang… - Journal of Cellular …, 2024 - Wiley Online Library
Along with mounting evidence that gut microbiota and their metabolites migrate
endogenously to distal organs, the 'gut–lung axis,''gut–brain axis,''gut–liver axis' and 'gut …

A Dichotomous role for FABP7 in sleep and Alzheimer's disease pathogenesis: a hypothesis

H Needham, G Torpey, CC Flores, CJ Davis… - Frontiers in …, 2022 - frontiersin.org
Fatty acid binding proteins (FABPs) are a family of intracellular lipid chaperone proteins
known to play critical roles in the regulation of fatty acid uptake and transport as well as …