The intestinal epithelium is a multicellular interface in close proximity to a dense microbial
milieu that is completely renewed every 3–5 days. Pluripotent stem cells reside at the crypt …

The intestine is a vital organ responsible for nutrient absorption, bile and waste excretion,
and a major site of host immunity. In order to keep up with daily demands, the intestine has …

Recent advances in the treatment of various cancers have resulted in the adaptation of
several novel immunotherapeutic strategies. Notably, the recent intervention through …

Tumorigenesis is a multistep process characterized by the acquisition of genetic and
epigenetic alterations. During the course of malignancy development, tumor cells acquire …

Stem cells and the niche in which they reside feature a complex microenvironment with
tightly regulated homeostasis, cell-cell interactions and dynamic regulation of metabolism. A …

The dynamics, distribution and activity of subcellular organelles are integral to regulating
cell shape changes during various physiological processes such as epithelial cell formation …

Disease susceptibility and resistance are important factors for the conservation of
endangered species, including elephants. We analyzed pathology data from 26 zoos and …

Age‐associated DNA‐methylation profiles have been used successfully to develop highly
accurate biomarkers of age (" epigenetic clocks") in humans, mice, dogs, and other species …

Early life events can lead to multiple diseases in adulthood. Previous studies suggested that
polysorbate 80 (P80) as a widely used emulsifier in pharmaceutical formulations and food …

Accumulating evidence strongly indicates that the presence of cancer stem cells (CSCs)
leads to the emergence of worse clinical scenarios, such as chemo-and radiotherapy …