This paper describes the contemporary state of knowledge regarding processes that
regulate normal development of the embryonic–fetal central nervous system (CNS). The …

ABSTRACT The 14‐3‐3 family of proteins are highly conserved acidic eukaryotic proteins
(25–32 kDa) abundantly present in the body. Through numerous binding partners, the 14‐3 …

Introduction Lissencephaly is a rare malformation of cortical development due to abnormal
transmantle migration resulting in absent or reduced gyration. The lissencephaly spectrum …

Extensive studies in the past 30 years have established that cyclin-dependent kinases
(CDKs) exert many diverse, important functions in a number of molecular and cellular …

Lissencephaly comprises a spectrum of malformations of cortical development. This
spectrum includes agyria, pachygyria, and subcortical band heterotopia; each represents …

After diagnosis of a fetal neurological anomaly, prospective parents want to know the best
and worst‐case scenarios and an estimation of the risk to their infant of having an atypical …

The central nervous system (CNS) is composed of the brain and the spinal cord. They both
develop from the embryonic ectoderm alongside other structures like the skin. Their …

The increase in understanding of molecular biology and recent advances in genetic testing
have caused rapid growth in knowledge of genetic causes of malformations of cortical …

Background Malformations of cortical development comprise phenotypically heterogeneous
conditions, and the diagnostic value of genetic testing in blood still remains to be elucidated …

Objectives: Identify the etiology of lissencephaly. Describe the evaluation of lissencephaly.
Outline the management options available for lissencephaly. Summarize interprofessional …