Human-based modelling and simulations are becoming ubiquitous in biomedical science
due to their ability to augment experimental and clinical investigations. Cardiac …

The slow I KS K+ channel plays a major role in repolarizing the cardiac action potential and
consists of the assembly of KCNQ1 and KCNE1 subunits. Mutations in either KCNQ1 or …

The entorhinal cortex (EC) is a significant component of the systems that underlie certain
forms of memory formation and recall. Evidence has been emerging that the dopaminergic …

Zn, an essential micronutrient and second most abundant trace element in cell and tissues,
reduces stool output when administered to children with acute diarrhea. The mechanism by …

Potassium channels form highly K+ ion-selective pores in the plasma membrane of excitable
cells. Voltagegated potassium (Kv) channels open in response to membrane depolarization …

Publicly available toxicological studies on wastewaters associated with unconventional oil
and gas (UOG) activities in offshore regions are nonexistent. The current study investigated …

Malpighian tubules of adult female yellow fever mosquitoes Aedes aegypti express three
inward rectifier K+(Kir) channel subunits: AeKir1, AeKir2B and AeKir3. Here we 1) elucidate …

TREK-1 is a member of the two-pore domain potassium channel family that is known as a
leak channel and plays a key role in many physiological and pathological processes. The …

Abstract KCNQ1–5 (Kv7. 1–7.5) subunits assemble to form a variety of functional K+
channels in the nervous system, heart, and epithelia. KCNQ1 and KCNQ4 homomers and …

Neurons regulate the propagation of chemoelectric signals throughout the nervous system
by opening and closing ion channels, a process known as gating. Here, histidine-based …