Chagas disease caused by the parasite Trypanosoma cruzi affects millions of people.
Although its first genome dates from 2005, its complexity hindered a complete assembly and …

Trypanosomes have complex life cycles within which there are both proliferative and
differentiation cell divisions. The coordination of the cell cycle to achieve these different …

Abstract Replication Protein A (RPA) is a broadly conserved complex comprised of the
RPA1, 2 and 3 subunits. RPA protects the exposed single-stranded DNA (ssDNA) during …

Leishmania are kinetoplastid pathogens that cause leishmaniasis, a debilitating and
potentially life-threatening infection if untreated. Unusually, Leishmania regulate their gene …

Various origin mapping approaches have enabled genome-wide identification of origins of
replication (ORI) in model organisms, but only a few studies have focused on divergent …

Abstract Background The Euglenozoa are a protist group with an especially rich history of
evolutionary diversity. They include diplonemids, representing arguably the most species …

DNA replication is needed to duplicate a cell's genome in S phase and segregate it during
cell division. Previous work in Leishmania detected DNA replication initiation at just a single …

Leishmaniases belong to the inglorious group of neglected tropical diseases, presenting
different degrees of manifestations severity. It is caused by the transmission of more than 20 …

R-loops are stable RNA–DNA hybrids that have been implicated in transcription initiation
and termination, as well as in telomere maintenance, chromatin formation, and genome …

Antigenic variation by variant surface glycoprotein (VSG) coat switching in African
trypanosomes is one of the most elaborate immune evasion strategies found among …