Rho-associated coiled-coil containing kinases (ROCK) structure, regulation, and functions
Rho-associated coiled-coil containing kinases (ROCK) were originally identified as effectors
of the RhoA small GTPase.–They belong to the AGC family of serine/threonine kinases and …
of the RhoA small GTPase.–They belong to the AGC family of serine/threonine kinases and …
The function of Rho-associated kinases ROCK1 and ROCK2 in the pathogenesis of cardiovascular disease
S Hartmann, AJ Ridley, S Lutz - Frontiers in pharmacology, 2015 - frontiersin.org
Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are
downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in …
downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in …
[HTML][HTML] ROCK inhibition in models of neurodegeneration and its potential for clinical translation
JC Koch, L Tatenhorst, AE Roser, KA Saal… - Pharmacology & …, 2018 - Elsevier
Neurodegenerative disorders like Parkinson's disease, Alzheimer's disease, or amyotrophic
lateral sclerosis are affecting a rapidly increasing population worldwide. While common …
lateral sclerosis are affecting a rapidly increasing population worldwide. While common …
Rho‐associated kinases in tumorigenesis: re‐considering ROCK inhibition for cancer therapy
N Rath, MF Olson - EMBO reports, 2012 - embopress.org
The Rho‐associated (ROCK) serine/threonine kinases have emerged as central regulators
of the actomyosin cytoskeleton, their main purpose being to promote contractile force …
of the actomyosin cytoskeleton, their main purpose being to promote contractile force …
Novel insights into the roles of Rho kinase in cancer
L Wei, M Surma, S Shi, N Lambert-Cheatham… - Archivum immunologiae …, 2016 - Springer
Rho-associated coiled-coil kinase (ROCK) is a major downstream effector of the small
GTPase RhoA. The ROCK family, consisting of ROCK1 and ROCK2, plays a central role in …
GTPase RhoA. The ROCK family, consisting of ROCK1 and ROCK2, plays a central role in …
Rho kinases in health and disease: from basic science to translational research
G Loirand, RM Touyz - Pharmacological reviews, 2015 - Elsevier
Rho-associated kinases ROCK1 and ROCK2 are key regulators of actin cytoskeleton
dynamics downstream of Rho GTPases that participate in the control of important …
dynamics downstream of Rho GTPases that participate in the control of important …
Rho-kinase: regulation,(dys) function, and inhibition
In a variety of normal and pathological cell types, Rho-kinases I and II (ROCKI/II) play a
pivotal role in the organization of the nonmuscle and smooth muscle cytoskeleton and …
pivotal role in the organization of the nonmuscle and smooth muscle cytoskeleton and …
Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil
Rho kinase (ROCK) is a major downstream effector of the small GTPase RhoA. ROCK
family, consisting of ROCK1 and ROCK2, plays central roles in the organization of actin …
family, consisting of ROCK1 and ROCK2, plays central roles in the organization of actin …
Helicobacter pylori exploits host membrane phosphatidylserine for delivery, localization, and pathophysiological action of the CagA oncoprotein
N Murata-Kamiya, K Kikuchi, T Hayashi, H Higashi… - Cell host & …, 2010 - cell.com
When delivered into gastric epithelial cells via type IV secretion, Helicobacter pylori CagA
perturbs host cell signaling and thereby promotes gastric carcinogenesis. However, the …
perturbs host cell signaling and thereby promotes gastric carcinogenesis. However, the …
[HTML][HTML] Pleckstrin Homology [PH] domain, structure, mechanism, and contribution to human disease
G Powis, EJ Meuillet, M Indarte, G Booher… - Biomedicine & …, 2023 - Elsevier
The pleckstrin homology [PH] domain is a structural fold found in more than 250 proteins
making it the 11th most common domain in the human proteome. 25% of family members …
making it the 11th most common domain in the human proteome. 25% of family members …