Since the late 1980s, mice have been repopulated with human hematopoietic cells to study
the fundamental biology of human hematopoiesis and immunity, as well as a broad range of …

Fibroblasts are highly heterogeneous mesenchymal stromal cells, and different fibroblast
subpopulations play different roles. A subpopulation of fibroblasts expressing CD90, a 25 …

The bone marrow microenvironment provides indispensable factors to sustain blood
production throughout life. It is also a hotspot for the progression of hematologic disorders …

The hematopoietic stem cell (HSC) niche is a specialized microenvironment, where a
complex and dynamic network of interactions across multiple cell types regulates HSC …

The bone marrow (BM) tissue is the main physiological site for adult hematopoiesis. In
recent years, the cellular and matrix components composing the BM have been defined with …

In hematological malignancies, leukemias or myelomas, malignant cells present bone
marrow (BM) homing, in which the niche contributes to tumor development and drug …

Technological limitations have hampered understanding of how individual molecules,
including putative stem cell regulators, are distributed throughout tissues and stem cell …

Ectopic'humanized ossicles'(hOss) are miniaturized, engineered human bone organs in
mice displaying a similar structure and function to native mouse bones. However, they are …

Highlights•In vivo ossicle models and ex vivo bioreactors are new models used to study
human hematopoiesis and leukemogenesis and the bone marrow microenvironment.• …

Tissue engineering opens multiple opportunities in regenerative medicine, drug testing, and
modeling of the hematopoiesis in health and disease. Recapitulating the organization of …