Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …

DHEA and DHEAS are steroids synthesized in human adrenals, but their function is unclear.
In addition to adrenal synthesis, evidence also indicates that DHEA and DHEAS are …

Leptin influences satiety, adiposity, and metabolism and is associated with mechanisms
regulating puberty onset, fertility, and pregnancy in various species. Maternal …

Dehydroepiandrosterone has been thought to have physiological functions other than as an
androgen precursor. The previous studies performed have demonstrated a number of …

A major achievement from 500 million years of evolution is the establishment of a high
secretion rate of dehydroepiandrosterone (DHEA) by the human adrenal glands coupled …

Dehydroepiandrosterone (DHEA) is a C19 steroid of adrenal origin. Notably, its secretion
declines with age, a phenomenon referred to as the “adrenopause”. For many years, the …

With the increasing knowledge that gender influences normal physiology, much biomedical
research has begun to focus on the differential effects of sex on tissue function. Sexual …

The biological significance of dehydroepiandrosterone (DHEA) which, in the form of its
sulfated ester is the most abundant steroid hormone in human plasma, is an enigma. Over …

The plasma levels of dehydroepiandrosterone (DHEA) and its sulfated form (DHEAS)
decline∼ 80% between the ages of 25 and 75 yr. Muscle mass and strength also decrease …

The gonadal steroids, including androgens, estrogens and progestogens, are involved in
the control of body fat distribution in humans. Nevertheless, not only the size and localization …