High-throughput glycomic methods
I Trbojević-Akmačić… - Chemical …, 2022 - ACS Publications
Glycomics aims to identify the structure and function of the glycome, the complete set of
oligosaccharides (glycans), produced in a given cell or organism, as well as to identify …
oligosaccharides (glycans), produced in a given cell or organism, as well as to identify …
[HTML][HTML] Immunoglobulin G glycosylation in aging and diseases
Abstract The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows
a significant degree of variation within populations. IgG glycome composition is influenced …
a significant degree of variation within populations. IgG glycome composition is influenced …
[HTML][HTML] IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy
S Shkunnikova, A Mijakovac, L Sironic, M Hanic… - Biotechnology …, 2023 - Elsevier
Immunoglobulin (IgG) glycosylation is a complex enzymatically controlled process, essential
for the structure and function of IgG. IgG glycome is relatively stable in the state of …
for the structure and function of IgG. IgG glycome is relatively stable in the state of …
Glycosylation of immunoglobulin G associates with clinical features of inflammatory bowel diseases
Background and Aims Causes of inflammatory bowel diseases are not well understood and
the most prominent forms, Crohn's disease (CD) and ulcerative colitis (UC), are sometimes …
the most prominent forms, Crohn's disease (CD) and ulcerative colitis (UC), are sometimes …
Immunoglobulin G glycans–Biomarkers and molecular effectors of aging
Immunoglobulin G (IgG) antibodies are post-translationally modified by the addition of
complex carbohydrate molecules–glycans, which have profound effects on the IgG function …
complex carbohydrate molecules–glycans, which have profound effects on the IgG function …
Profiling and genetic control of the murine immunoglobulin G glycome
J Krištić, OO Zaytseva, R Ram, Q Nguyen… - Nature chemical …, 2018 - nature.com
Immunoglobulin G (IgG) glycosylation is essential for function of the immune system, but the
genetic and environmental factors that underlie its inter-individual variability are not well …
genetic and environmental factors that underlie its inter-individual variability are not well …
The role of N-glycosylation in B-cell biology and IgG activity. The aspects of autoimmunity and anti-inflammatory therapy
S Trzos, P Link-Lenczowski, E Pocheć - Frontiers in Immunology, 2023 - frontiersin.org
The immune system is strictly regulated by glycosylation through the addition of highly
diverse and dynamically changing sugar structures (glycans) to the majority of immune cell …
diverse and dynamically changing sugar structures (glycans) to the majority of immune cell …
[HTML][HTML] Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 …
Summary Background People with Down syndrome (DS) show clinical signs of accelerated
ageing. Causative mechanisms remain unknown and hypotheses range from the …
ageing. Causative mechanisms remain unknown and hypotheses range from the …
Nanosponges: an overlooked promising strategy to combat SARS-CoV-2
Highlights•Nanosponges are explored for their antiviral delivery and biological
neutralization potentials.•Cellular nanosponges block interactions between SARS-CoV-2 …
neutralization potentials.•Cellular nanosponges block interactions between SARS-CoV-2 …
CD16a with oligomannose-type N-glycans is the only “low-affinity” Fc γ receptor that binds the IgG crystallizable fragment with high affinity in vitro
Fc γ receptors (FcγRs) bind circulating IgG (IgG1) at the surface of leukocytes. Antibodies
clustered at the surface of a targeted particle trigger a protective immune response through …
clustered at the surface of a targeted particle trigger a protective immune response through …