Gram‐positive uropathogens, polymicrobial urinary tract infection, and the emerging microbiota of the urinary tract

KA Kline, AL Lewis - Urinary tract infections: molecular …, 2017 - Wiley Online Library
Uncomplicated urinary‐tract infection (UTI) is most common in young, sexually active,
nonpregnant, premenopausal women. Gram‐negative bacteria are isolated from 75% to …

Infection in an aging population

KA Kline, DME Bowdish - Current opinion in microbiology, 2016 - Elsevier
Highlights•One third of deaths in adults in the elderly are due to infectious disease.•Changes
in the aging immune response increase the risk of infection in the elderly.•Respiratory …

Group B streptococcal maternal colonization and neonatal disease: molecular mechanisms and preventative approaches

KA Patras, V Nizet - Frontiers in pediatrics, 2018 - frontiersin.org
Group B Streptococcus (GBS) colonizes the gastrointestinal and vaginal epithelium of a
significant percentage of healthy women, with potential for ascending intrauterine infection …

Direct detection of tissue-resident bacteria and chronic inflammation in the bladder wall of postmenopausal women with recurrent urinary tract infection

NJ De Nisco, M Neugent, J Mull, L Chen… - Journal of molecular …, 2019 - Elsevier
Urinary tract infections (UTIs) are the most commonly reported infections in adult women and
have high rates of recurrence, especially in postmenopausal women. Recurrent UTI (RUTI) …

[HTML][HTML] Roles of the vagina and the vaginal microbiota in urinary tract infection: evidence from clinical correlations and experimental models

AL Lewis, NM Gilbert - GMS infectious diseases, 2020 - ncbi.nlm.nih.gov
Mounting evidence indicates that the vagina can harbor uropathogenic bacteria. Here, we
consider three roles played by the vagina and its bacterial inhabitants in urinary tract …

Transient microbiota exposures activate dormant Escherichia coli infection in the bladder and drive severe outcomes of recurrent disease

NM Gilbert, VP O'Brien, AL Lewis - PLoS pathogens, 2017 - journals.plos.org
Pathogens often inhabit the body asymptomatically, emerging to cause disease in response
to unknown triggers. In the bladder, latent intracellular Escherichia coli reservoirs are …

Polymicrobial interactions in the urinary tract: is the enemy of my enemy my friend?

JR Gaston, AO Johnson, KL Bair, AN White… - Infection and …, 2021 - Am Soc Microbiol
The vast majority of research pertaining to urinary tract infection has focused on a single
pathogen in isolation and predominantly Escherichia coli. However, polymicrobial urine …

A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease

VP O'brien, TJ Hannan, L Yu, J Livny, E Roberson… - Nature …, 2016 - nature.com
Recurrent bacterial infections are a significant burden worldwide, and prior history of
infection is often a significant risk factor for developing new infections. For urinary tract …

Strengths and limitations of model systems for the study of urinary tract infections and related pathologies

AE Barber, JP Norton, TJ Wiles… - … and Molecular Biology …, 2016 - Am Soc Microbiol
Urinary tract infections (UTIs) are some of the most common bacterial infections worldwide
and are a source of substantial morbidity among otherwise healthy women. UTIs can be …

An Overview of Two-Component Signal Transduction Systems Implicated in Extra-Intestinal Pathogenic E. coli Infections

EJ Breland, AR Eberly… - Frontiers in cellular and …, 2017 - frontiersin.org
Extra-intestinal pathogenic E. coli (ExPEC) infections are common in mammals and birds.
The predominant ExPEC types are avian pathogenic E. coli (APEC), neonatal meningitis …