DNA repair in mammalian cells involves the coordinated action of a range of complex
cellular repair machinery. Our understanding of these DNA repair processes has advanced …

In the past decades, the broad selection of CRISPR-Cas systems has revolutionized
biotechnology by enabling multimodal genetic manipulation in diverse organisms. Rooted in …

Engineering metabolism to efficiently produce chemicals from multi-step pathways requires
optimizing multi-gene expression programs to achieve enzyme balance. CRISPR-Cas …

Background Threshold-dependent gene drives (TDGDs) could be used to spread desirable
traits through a population, and are likely to be less invasive and easier to control than …

Successful resistance to disease-causing pathogens is underpinned by properly regulated
immune signalling and defence responses in plants. The plant immune system is controlled …

Understanding how gene expression impacts plant development and physiology is
important for rationally engineering improved crops. Programmable Transcriptional …

Agriculture is a centuries old practice that has selected upon natural variation over time.
Highly productive cultivars today are the result of this selection. DNA sequencing has …