Nuclear factor erythroid 2-related factor 2 in regulating cancer metabolism
Significance: Nuclear factor erythroid 2 (NFE2)-related factor 2 (NFE2L2, or NRF2) is a
transcription factor predominantly affecting the expression of antioxidant genes. NRF2 plays …
transcription factor predominantly affecting the expression of antioxidant genes. NRF2 plays …
EGFR-TNFR1 pathway in endothelial cell facilitates acute lung injury by NF-κB/MAPK-mediated inflammation and RIP3-dependent necroptosis
H Zhang, X Zhang, C Ling, S Hua, Z Xiong… - International …, 2023 - Elsevier
Tumor necrosis factor-α (TNFα) has emerged as a pivotal effector critically correlated with
disease severity in acute lung injury (ALI). Because both the excessive activation of …
disease severity in acute lung injury (ALI). Because both the excessive activation of …
Lapatinib ditosylate rescues memory impairment in D-galactose/ovariectomized rats: Potential repositioning of an anti-cancer drug for the treatment of Alzheimer's …
HM Mansour, HM Fawzy, AS El-Khatib… - Experimental neurology, 2021 - Elsevier
Epidermal growth factor receptor (EGFR) signaling plays a substantial role in learning and
memory. The upregulation of EGFR has been embroiled in the pathophysiology of …
memory. The upregulation of EGFR has been embroiled in the pathophysiology of …
Euphorbium total triterpenes improve Freund's complete adjuvant-induced arthritis through PI3K/AKT/Bax and NF-κB/NLRP3 signaling pathways
M Zhou, W Tan, J Liu, Z Gu, J Zhao - Journal of Ethnopharmacology, 2023 - Elsevier
Ethnopharmacological relevance Euphorbium is the resinous secretion of Euphorbia
resinifera Berg. According to the record, Euphorbium was first used by Roman doctors to …
resinifera Berg. According to the record, Euphorbium was first used by Roman doctors to …
The protective effects of curculigoside A on adjuvant-induced arthritis by inhibiting NF-кB/NLRP3 activation in rats
H Ding, G Gao, L Zhang, G Shen, W Sun, Z Gu… - International …, 2016 - Elsevier
The purpose of this study was to investigate the protective effects of curculigoside A (CA) on
adjuvant arthritis (AA) rats and explore its possible mechanisms. AA was induced by …
adjuvant arthritis (AA) rats and explore its possible mechanisms. AA was induced by …
[HTML][HTML] A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells
HS Khalil, SP Langdon, A Goltsov, T Soininen… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Nuclear erythroid related factor-2 (NRF2) is known to promote cancer therapeutic
detoxification and crosstalk with growth promoting pathways. HER2 receptor tyrosine kinase …
detoxification and crosstalk with growth promoting pathways. HER2 receptor tyrosine kinase …
[HTML][HTML] Polyene phosphatidylcholine inhibited the inflammatory response in LPS-stimulated macrophages and ameliorated the adjuvant-induced rat arthritis
W Pan, WT Hao, H Xu, SP Qin, XY Li… - American journal of …, 2017 - ncbi.nlm.nih.gov
This study sought to investigate the anti-inflammatory effect of Polyene Phosphatidylcholine
(PPC), a clinical drug that is used to treat hepatopathy, on lipopolysaccharide (LPS) …
(PPC), a clinical drug that is used to treat hepatopathy, on lipopolysaccharide (LPS) …
Transdermal delivery of triptolide–phospholipid complex to treat rheumatoid arthritis
XY Liu, WJ Pei, YZ Wu, FL Ren, SY Yang, X Wang - Drug Delivery, 2021 - Taylor & Francis
The aim of this study was to develop and evaluate a triptolide phospholipid complex (TPCX)
for the treatment of rheumatoid arthritis (RA) by transdermal delivery. TPCX was prepared …
for the treatment of rheumatoid arthritis (RA) by transdermal delivery. TPCX was prepared …
Identification of fused pyrimidines as interleukin 17 secretion inhibitors
Inhibiting the interleukin 17 pathway is of interest in a number of autoimmune diseases.
Herein, 42 fused pyrimidines have been evaluated as interleukin 17 secretion inhibitors …
Herein, 42 fused pyrimidines have been evaluated as interleukin 17 secretion inhibitors …
Prediction of new risk genes and potential drugs for rheumatoid arthritis from multiomics data
Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease for which there is a
lack of therapeutic options. Genome‐wide association studies (GWASs) have identified over …
lack of therapeutic options. Genome‐wide association studies (GWASs) have identified over …