The ribosome is a complex molecular machine composed of numerous distinct proteins and
nucleic acids and is responsible for protein synthesis in every living cell. Ribosome …

Biomolecular condensates are two-and three-dimensional compartments in eukaryotic cells
that concentrate specific collections of molecules without an encapsulating membrane …

The frequent occurrence of transcription and DNA replication in cells results in many
encounters, and thus conflicts, between the transcription and replication machineries. These …

The nucleolus is the major site for synthesis of ribosomes, complex molecular machines that
are responsible for protein synthesis. A wealth of research over the past 20 years has clearly …

The nucleolus is a sub-nuclear body known primarily for its role in ribosome biogenesis.
Increased number and/or size of nucleoli have historically been used by pathologists as a …

Recent studies show that nuclear RNase P is linked to chromatin structure and function.
Thus, variants of this ribonucleoprotein (RNP) complex bind to chromatin of small noncoding …

Background Fusion of DNA methyltransferase domains to the nuclease-deficient clustered
regularly interspaced short palindromic repeat (CRISPR) associated protein 9 (dCas9) has …

Replication stress (RS) is a characteristic state of cancer cells as they tend to exchange
precision of replication for fast proliferation and increased genomic instability. To overcome …

RNA polymerase I (Pol I) synthesizes about 60% of cellular RNA by transcribing multiple
copies of the ribosomal RNA gene (rDNA). The transcriptional activity of Pol I controls the …

Telomeres and genes encoding 45S ribosomal RNA (rDNA) are frequently located adjacent
to each other on eukaryotic chromosomes. Although their primary roles are different, they …