Granzymes are a family of small (∼ 32 kDa) serine proteases with a range of substrate
specificities that are stored in, and released from, the cytoplasmic secretory vesicles …

T cell survival, differentiation after stimulation, and function are intrinsically linked to distinct
cellular metabolic states. The ability of T cells to readily transition between metabolic states …

Chronic apical periodontitis is a prevalent oral disease characterized by bone loss, and its
underlying mechanisms remain unclear. This study aimed to investigate the role and …

Krill oil (KO) is rich in bioactive ingredients including phospholipids, omega-3 fatty acids,
and astaxanthin. While health benefits and roles of KO in modulating lipid metabolism are …

The activation and mobilization of immune cells play a crucial role in immunotherapy.
Existing therapeutic interventions, such as cytokines administration, aim to enhance immune …

CD8 T cells expressing granzyme K are enriched in synovial tissue from patients with
rheumatoid arthritis and in tissues affected by several other autoimmune diseases. The roles …

Granzymes are a family of serine-proteases that act as critical mediators in the cytolytic and
immunomodulatory activities of immune cells such as CD8+ T-cells and natural killer (NK) …

The" innate-like" T cell compartment, known as T inn, represents a diverse group of T cells
that straddle the boundary between innate and adaptive immunity. We explore the …

Psoriasis is an inflammatory disease with systemic manifestations that most commonly
presents as itchy, erythematous, scaly plaques on extensor surfaces. Activation of the IL …

In this study, we utilized microarray profiles, specifically GSE71220 and GSE11393 obtained
from the GEO database, which provide gene expression data from blood samples. Through …