Pathological overeating: emerging evidence for a compulsivity construct

CF Moore, V Sabino, GF Koob, P Cottone - Neuropsychopharmacology, 2017 - nature.com
Compulsive eating behavior is a transdiagnostic construct that is characteristic of medical
and psychiatric conditions such as forms of obesity and eating disorders. Although feeding …

Overlap of food addiction and substance use disorders definitions: analysis of animal and human studies

A Hone-Blanchet, S Fecteau - Neuropharmacology, 2014 - Elsevier
Food has both homeostatic and hedonic components, which makes it a potent natural
reward. Food related reward could therefore promote an escalation of intake and trigger …

High trait impulsivity predicts food addiction-like behavior in the rat

C Velázquez-Sánchez, A Ferragud, CF Moore… - …, 2014 - nature.com
Impulsivity is a behavioral trait frequently seen not only in drug-addicted individuals but also
in individuals who pathologically overeat. However, whether impulsivity predates the …

The neurobiology of binge-eating disorder compared with obesity: implications for differential therapeutics

RG Boswell, MN Potenza, CM Grilo - Clinical therapeutics, 2021 - Elsevier
Purpose Emerging work indicates divergence in the neurobiologies of binge-eating disorder
(BED) and obesity despite their frequent co-occurrence. This review highlights specific …

Binge-eating disorder: clinical and therapeutic advances

PH Hutson, IM Balodis, MN Potenza - Pharmacology & therapeutics, 2018 - Elsevier
Binge-eating disorder (BED) is the most prevalent eating disorder with estimates of 2–5% of
the general adult population. Nonetheless, its pathophysiology is poorly understood …

The trace amine-associated receptor 1 agonist RO5256390 blocks compulsive, binge-like eating in rats

A Ferragud, AD Howell, CF Moore, TL Ta… - …, 2017 - nature.com
Compulsive, binge eating of highly palatable food constitutes a core feature of some forms of
obesity and eating disorders, as well as of the recently proposed disorder of food addiction …

Neuroscience of compulsive eating behavior

CF Moore, V Sabino, GF Koob, P Cottone - Frontiers in neuroscience, 2017 - frontiersin.org
A systematic characterization of compulsivity in pathological forms of eating has been
proposed in the context of three functional domains:(1) habitual overeating;(2) overeating to …

Effects of Δ9-Tetrahydrocannibinol (THC) on obesity at different stages of life: a literature review

N Fearby, S Penman, P Thanos - International Journal of Environmental …, 2022 - mdpi.com
The Cannabis sativa plant has historically been used for both recreational and medical
purposes. With the recent surge in recreational use of cannabis among adolescents and …

Targeting the endocannabinoid CB1 receptor to treat body weight disorders: a preclinical and clinical review of the therapeutic potential of past and present CB1 drugs

T Murphy, B Le Foll - Biomolecules, 2020 - mdpi.com
Obesity rates are increasing worldwide and there is a need for novel therapeutic treatment
options. The endocannabinoid system has been linked to homeostatic processes, including …

The uncompetitive N-methyl-D-aspartate antagonist memantine reduces binge-like eating, food-seeking behavior, and compulsive eating: role of the nucleus …

KL Smith, RR Rao, C Velázquez-Sánchez… - …, 2015 - nature.com
Binge-eating disorder is characterized by excessive, uncontrollable consumption of
palatable food within brief periods of time. The role of the glutamatergic N-methyl-D …