Immune system abnormalities in schizophrenia: an integrative view and translational perspectives

EA Ermakov, MM Melamud, VN Buneva… - Frontiers in …, 2022 - frontiersin.org
The immune system is generally known to be the primary defense mechanism against
pathogens. Any pathological conditions are reflected in anomalies in the immune system …

Anti-double stranded DNA antibodies: origin, pathogenicity, and targeted therapies

X Wang, Y Xia - Frontiers in immunology, 2019 - frontiersin.org
Systemic lupus erythematosus (SLE) is characterized by high-titer serological
autoantibodies, including antibodies that bind to double-stranded DNA (dsDNA). The origin …

[HTML][HTML] A clinical approach to new-onset psychosis associated with immune dysregulation: the concept of autoimmune psychosis

S Najjar, J Steiner, A Najjar, K Bechter - Journal of Neuroinflammation, 2018 - Springer
Growing data point to the overlap between psychosis and pathological processes
associated with immunological dysregulation as well as inflammation. Notably, the recent …

Immunoglobulins with non-canonical functions in inflammatory and autoimmune disease states

EA Ermakov, GA Nevinsky, VN Buneva - International journal of molecular …, 2020 - mdpi.com
Immunoglobulins are known to combine various effector mechanisms of the adaptive and
the innate immune system. Classical immunoglobulin functions are associated with antigen …

Autoimmune processes in multiple sclerosis: Production of harmful catalytic antibodies associated with significant changes in the hematopoietic stem cell …

GA Nevinsky - Trending Topics in Multiple Sclerosis, 2016 - books.google.com
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. MS
pathogenesis is not clear. Destruction of myelin by inflammation caused by autoimmune …

Autoimmunity and immune system dysregulation in schizophrenia: IgGs from sera of patients hydrolyze myelin basic protein

D Parshukova, LP Smirnova… - Journal of Molecular …, 2019 - Wiley Online Library
Several different theories of schizophrenia (SCZ) were discussed; the causes of this disease
are not yet clear. Using ELISA, it was shown that titers of autoantibodies against myelin …

Natural IgG against S-protein and RBD of SARS-CoV-2 do not bind and hydrolyze DNA and are not autoimmune

AM Timofeeva, SE Sedykh, EA Ermakov… - International Journal of …, 2022 - mdpi.com
Since the onset of the COVID-19 pandemic, numerous publications have appeared
describing autoimmune pathologies developing after a coronavirus infection, with several …

Catalytic antibodies in norm and systemic lupus erythematosus

GA Nevinsky - Lupus; Khan, WA, Ed.; InTech: Rijeka, Croatia, 2017 - books.google.com
Systemic lupus erythematosus (SLE) is known as a systemic polyethiologic diffuse
autoimmune disease characterized by connective tissue disorganization and the paramount …

Microglia and other cellular mediators of immunological dysfunction in schizophrenia: a narrative synthesis of clinical findings

KD Nguyen, A Amerio, A Aguglia, L Magnani, A Parise… - Cells, 2023 - mdpi.com
Schizophrenia is a complex psychiatric condition that may involve immune system
dysregulation. Since most putative disease mechanisms in schizophrenia have been …

Some structural features of the peptide profile of myelin basic protein-hydrolyzing antibodies in schizophrenic patients

M Zavialova, D Kamaeva, L Kazieva, VS Skvortsov… - PeerJ, 2023 - peerj.com
The antibodies of schizophrenic patients that hydrolyze myelin basic protein (MBP) have
been actively studied recently, but the mechanism of the catalytic properties of …