Alzheimer's disease (AD) is an aging-related neurological disorder characterized by
synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction …

Growing evidence suggests that synaptic signaling is compromised in the aging brain and in
Alzheimer's disease (AD), contributing to synaptic decline. Wnt signaling is a prominent …

Synaptic dysfunction is closely related to Alzheimer's disease (AD) which is also recognized
as synaptic disorder. β-amyloid (Aβ) is one of the main pathogenic factors in AD, which …

Wnts comprise a large family of proteins that have shown to be part of a signaling cascade
that regulates several aspects of development including organogenesis, midbrain …

Localized protein synthesis requires assembly and transport of translationally silenced
ribonucleoprotein particles (RNPs), some of which are exceptionally large. Where in the cell …

The Wnt signaling pathway plays a role in the development of the central nervous system
and growing evidence indicates that Wnts also regulates the structure and function of the …

Alzheimer's disease (AD) is the most prevalent form of dementia in the elderly. Alterations
capable of causing brain circuitry dysfunctions in AD may take several years to develop …

Alzheimer's disease (AD) is an age-related neurological disorder characterized by synaptic
loss and dementia. The low-density lipoprotein receptor-related protein 6 (LRP6) is an …

Synaptic dysfunction is widely proposed as an initial insult leading to the neurodegeneration
observed in Alzheimer's disease (AD). We hypothesize that the initial insult originates in the …

In the adult brain new neurons are continuously generated mainly in two regions, the
subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) in the …