Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo

JA Villadangos, P Schnorrer - Nature Reviews Immunology, 2007 - nature.com
Dendritic cells (DCs) comprise several subsets, and their roles in the presentation of
antigens derived from pathogens, vaccines and self tissues are now beginning to be …

Recent advances in antigen processing and presentation

PE Jensen - Nature immunology, 2007 - nature.com
Heterogeneous intracellular pathways and biochemical mechanisms are responsible for
generating the glycoprotein complexes of peptide and major histocompatibility complex that …

Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse

F Crawford, B Stadinski, N Jin… - Proceedings of the …, 2011 - National Acad Sciences
In the nonobese diabetic (NOD) mouse model of type 1 diabetes (T1D), an insulin peptide
(B: 9–23) is a major target for pathogenic CD4+ T cells. However, there is no consensus on …

Lymph formation, composition and circulation: a proteomics perspective

KC Hansen, A D'Alessandro, CC Clement… - International …, 2015 - academic.oup.com
During the last 20 years a deeper understanding of the lymphatic circulatory system, lymph
formation and composition has emerged. This review will examine the current knowledge on …

Pharmacological modulation of host immunity with hen egg white lysozyme (HEWL)—A review

A Bergamo, G Sava - Molecules, 2023 - mdpi.com
In the 100 years since its discovery, lysozyme has become an important molecule, both as
model for studies in different fields and as a candidate for the therapy of various pathological …

Comparing pooled peptides with intact protein for accessing cross-presentation pathways for protective CD8+ and CD4+ T cells

H Zhang, H Hong, D Li, S Ma, Y Di, A Stoten… - Journal of Biological …, 2009 - ASBMB
To better understand the mechanisms of intracellular trafficking and presentation of
exogenous peptides by antigen-presenting cells (APC), we compared the handling of …

The dendritic cell major histocompatibility complex II (MHC II) peptidome derives from a variety of processing pathways and includes peptides with a broad spectrum of …

CC Clement, A Becerra, L Yin, V Zolla, L Huang… - Journal of Biological …, 2016 - ASBMB
The repertoire of peptides displayed in vivo by MHC II molecules derives from a wide
spectrum of proteins produced by different cell types. Although intracellular endosomal …

Investigation into Cardiac Myhc-α 334–352-Specific TCR Transgenic Mice Reveals a Role for Cytotoxic CD4 T Cells in the Development of Cardiac Autoimmunity

M Sur, MT Rasquinha, K Mone, C Massilamany… - Cells, 2024 - mdpi.com
Myocarditis is one of the major causes of heart failure in children and young adults and can
lead to dilated cardiomyopathy. Lymphocytic myocarditis could result from autoreactive …

The lymphatic fluid

L Santambrogio - International review of cell and molecular biology, 2018 - Elsevier
This review will highlight our current understanding of the formation, circulation, and
immunological role of lymphatic fluid. The formation of the extracellular fluid depends on the …

The melting pot of the MHC II peptidome

LJ Stern, L Santambrogio - Current opinion in immunology, 2016 - Elsevier
Highlights•MHCII present antigens from a variety of intracellular and extracellular
sources.•Endosomal and non-endosomal processing pathways contribute to the MHCII …