Cyclooxygenase-2 (COX-2) as a target of anticancer agents: A review of novel synthesized scaffolds having anticancer and COX-2 inhibitory potentialities
Cancer is a serious threat to human beings and is the second-largest cause of death all over
the globe. Chemotherapy is one of the most common treatments for cancer; however, drug …
the globe. Chemotherapy is one of the most common treatments for cancer; however, drug …
Inhibitory activities of indolizine derivatives: a patent review
Introduction Indolizines are structural isomers with indoles. Although several indole-based
commercial drugs are available in the market, none of the indolizine-based drugs are …
commercial drugs are available in the market, none of the indolizine-based drugs are …
Design and synthesis of novel quinoline/chalcone/1, 2, 4-triazole hybrids as potent antiproliferative agent targeting EGFR and BRAFV600E kinases
New quinoline/chalcone hybrids containing 1, 2, 4-triazole moiety have been designed,
synthesized and their structures elucidated and confirmed by various spectroscopic …
synthesized and their structures elucidated and confirmed by various spectroscopic …
Design and synthesis of novel 2, 3-dihydropyrazino [1, 2-a] indole-1, 4-dione derivatives as antiproliferative EGFR and BRAFV600E dual inhibitors
Recent studies have shown additive and synergistic effects associated with the combination
of kinase inhibitors. BRAF V600E and EGFR are attractive targets for many diseases …
of kinase inhibitors. BRAF V600E and EGFR are attractive targets for many diseases …
Proapoptotic Activity of Achillea membranacea Essential Oil and Its Major Constituent 1,8-Cineole against A2780 Ovarian Cancer Cells
Among the hundreds of reported Achillea species, A. membranacea (Labill.) DC. is one of
the six that grow in Jordan. Many species of this genus are used in folk medicine to treat a …
the six that grow in Jordan. Many species of this genus are used in folk medicine to treat a …
Novel 1, 2, 4-triazole derivatives as apoptotic inducers targeting p53: Synthesis and antiproliferative activity
A series of novel thiazolo [3, 2-b][1, 2, 4]-triazoles 3a-n has been synthesized and evaluated
in vitro as potential antiproliferative. Compounds 3b-d exhibited significant antiproliferative …
in vitro as potential antiproliferative. Compounds 3b-d exhibited significant antiproliferative …
Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: A review
M Bian, Q Ma, Y Wu, H Du… - Journal of enzyme …, 2021 - Taylor & Francis
Inflammation and disease are closely related. Inflammation can induce various diseases,
and diseases can promote inflammatory response, and two possibly induces each other in a …
and diseases can promote inflammatory response, and two possibly induces each other in a …
Design, synthesis and antitrypanosomal activity of heteroaryl-based 1, 2, 4-triazole and 1, 3, 4-oxadiazole derivatives
Abstract Two series of novel 1, 2, 4-triazol-3-yl-thioacetamide 3a-b and 4a-b and 5-pyrazin-2-
yl-3H-[1, 3, 4] oxadiazole-2-thiones 9a-h were designed and synthesized. The compounds …
yl-3H-[1, 3, 4] oxadiazole-2-thiones 9a-h were designed and synthesized. The compounds …
Pharmacophore-based virtual screening, synthesis, biological evaluation, and molecular docking study of novel pyrrolizines bearing urea/thiourea moieties with …
In the current study, virtual screening of a small library of 1302 pyrrolizines bearing
urea/thiourea moieties was performed. The top-scoring hits were synthesised and evaluated …
urea/thiourea moieties was performed. The top-scoring hits were synthesised and evaluated …
Design, synthesis and biological evaluation of novel 5-((substituted quinolin-3-yl/1-naphthyl) methylene)-3-substituted imidazolidin-2, 4-dione as HIV-1 fusion …
TS Ibrahim, RM Bokhtia, AMM Al-Mahmoudy… - Bioorganic …, 2020 - Elsevier
A series of novel 5-(substituted quinolin-3-yl or 1-naphthyl) methylene)-3-substituted
imidazolidin-2, 4-dione 9–26 was designed and synthesized. The prepared compounds …
imidazolidin-2, 4-dione 9–26 was designed and synthesized. The prepared compounds …