The pentose phosphate pathway (PPP) is a glucose-oxidizing pathway that runs in parallel
to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide …

The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

Arthritis typically involves recurrence and progressive worsening at specific predilection
sites, but the checkpoints between remission and persistence remain unknown. Here, we …

Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are
susceptible to senescence during aging. We demonstrate the importance of the amount of …

Although disrupted bile acid (BA) homeostasis is implicated in inflammatory bowel disease
(IBD), the role of hepatic BA metabolism in the pathogenesis of colitis is poorly understood …

The ability to expand hematopoietic stem and progenitor cells (HSPCs) ex vivo is critical to
fully realize the potential of HSPC-based therapies. In particular, the application of clinically …

Cancer cells adapt cellular metabolism to cope with their high proliferation rate. Instead of
primarily using oxidative phosphorylation (OXPHOS), cancer cells use less efficient …

Dysregulated expression of the transcription factor MYCN is frequently detected in nervous
system tumors such as childhood neuroblastoma. Here, gene amplification of MYCN is a …

Metabolic characteristics of adult stem cells are distinct from their differentiated progeny, and
cellular metabolism is emerging as a potential driver of cell fate conversions,,–. How these …

An appropriate balance between self-renewal and differentiation is crucial for stem cell
function during both early development and tissue homeostasis throughout life. Recent …