The dopaminergic system plays important roles in neuromodulation, such as motor control,
motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a …

Parkinson's disease (PD) is a devastating and highly prevalent neurodegenerative disease
for which only symptomatic treatment is available. In order to develop a truly effective …

Dopamine metabolism, alpha-synuclein pathology, and iron homeostasis have all been
implicated as potential contributors to the unique vulnerability of substantia nigra …

Alzheimer's disease (AD) is neuropathologically characterized by the intracellular
accumulation of hyperphosphorylated tau and the extracellular deposition of amyloid-β …

Innocuous touch of the skin is detected by distinct populations of neurons, the low-threshold
mechanoreceptors (LTMRs), which are classified as Aβ-, Aδ-, and C-LTMRs. Here, we report …

Background: Ever since the pioneering reports in the 60s, L-3, 4-Dioxyphenylalanine
(levodopa) has represented the gold standard for the treatment of Parkinson's Disease (PD) …

Parkinson's disease (PD) is an aging-related disease and the second most common
neurodegenerative disease after Alzheimer's disease. The main symptoms of PD are …

Parkinson's disease (PD) coincides with a dramatic loss of dopaminergic neurons within the
substantia nigra. A key player in the loss of dopaminergic neurons is oxidative stress …

Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

Aromatic amino acids in the brain function as precursors for the monoamine
neurotransmitters serotonin (substrate tryptophan) and the catecholamines [dopamine …