The extracellular matrix (ECM) is synthesized and secreted by embryonic cells beginning at
the earliest stages of development. Our understanding of ECM composition, structure and …

The mammalian kidney forms via cell–cell interactions between an epithelial outgrowth of
the nephric duct and the surrounding nephrogenic mesenchyme. Initial morphogenetic …

The goal of this study was the production of a decellularized kidney scaffold with structural,
mechanical, and physiological properties necessary for engineering basic renal structures in …

Membrane type 1-matrix metalloprotease (MT1-MMP or MMP-14) is a major activator of pro-
MMP-2 and is essential for skeletal development. We show here that it is required for …

Although traditionally recognized for maintaining extracellular matrix integrity during
morphogenesis, the function of matrix metallo-proteinases (MMPs) and their inhibitors, the …

Because of the short half-life, either systemic or local administration of bFGF shows
significant drawbacks to spinal injury. In this study, an acellular spinal cord scaffold (ASC) …

Snail family transcriptional repressors regulate epithelial mesenchymal transitions during
physiological and pathological processes. A conserved SNAG repression domain present in …

When decellularizing kidneys, it is important to maintain the integrity of the acellular
extracellular matrix (ECM), including associated adhesion proteins and growth factors that …

Low birth weight due to intrauterine growth restriction is associated with various diseases in
adulthood, such as hypertension, cardiovascular disease, insulin resistance and end-stage …

Extracellular matrix (ECM) coatings have been used to improve cell performance in
bioartificial kidneys (BAKs). However, their effects on primary human renal proximal tubule …