Alpha7 nicotinic acetylcholine receptors in lung inflammation and carcinogenesis: Friends or foes?
K Hajiasgharzadeh, S Sadigh‐Eteghad… - Journal of cellular …, 2019 - Wiley Online Library
The lung tissue expresses the cholinergic system including nicotinic acetylcholine receptors
(nAChRs) which included in many physiologic and pathologic processes. Mounting …
(nAChRs) which included in many physiologic and pathologic processes. Mounting …
The dual role of alpha7 nicotinic acetylcholine receptor in inflammation-associated gastrointestinal cancers
Alpha7 nicotinic acetylcholine receptor (α7nAChR) is one of the main subtypes of nAChRs
that modulates various cancer-related properties including proliferative, anti-apoptotic, pro …
that modulates various cancer-related properties including proliferative, anti-apoptotic, pro …
Human secreted Ly-6/uPAR related protein-1 (SLURP-1) is a selective allosteric antagonist of α7 nicotinic acetylcholine receptor
EN Lyukmanova, MA Shulepko, D Kudryavtsev… - PLoS …, 2016 - journals.plos.org
SLURP-1 is a secreted toxin-like Ly-6/uPAR protein found in epithelium, sensory neurons
and immune cells. Point mutations in the slurp-1 gene cause the autosomal inflammation …
and immune cells. Point mutations in the slurp-1 gene cause the autosomal inflammation …
SLURP-1 controls growth and migration of lung adenocarcinoma cells, forming a complex with α7-nAChR and PDGFR/EGFR heterodimer
ML Bychkov, MA Shulepko, OV Shlepova… - Frontiers in Cell and …, 2021 - frontiersin.org
Secreted Ly6/uPAR-related protein 1 (SLURP-1) is a secreted Ly6/uPAR protein that
negatively modulates the nicotinic acetylcholine receptor of α7 type (α7-nAChR) …
negatively modulates the nicotinic acetylcholine receptor of α7 type (α7-nAChR) …
Lynx prototoxins: Roles of endogenous mammalian neurotoxin-like proteins in modulating nicotinic acetylcholine receptor function to influence complex biological …
JM Miwa, KR Anderson, KM Hoffman - Frontiers in pharmacology, 2019 - frontiersin.org
The cholinergic system modulates many biological functions, due to the widespread
distribution of cholinergic neuronal terminals, and the diffuse release of its neurotransmitter …
distribution of cholinergic neuronal terminals, and the diffuse release of its neurotransmitter …
Selective targeting of α7 nicotinic acetylcholine receptor by synthetic peptide mimicking loop I of human SLURP-1 provides efficient and prolonged therapy of …
OV Shlepova, MA Shulepko, VO Shipunova… - Frontiers in Cell and …, 2023 - frontiersin.org
α7-Type nicotinic acetylcholine receptor (α7-nAChR) promotes the growth and metastasis of
solid tumors. Secreted Ly6/uPAR-Related Protein 1 (SLURP-1) is a specific negative …
solid tumors. Secreted Ly6/uPAR-Related Protein 1 (SLURP-1) is a specific negative …
Three-finger proteins from the Ly6/uPAR family: functional diversity within one structural motif
NA Vasilyeva, EV Loktyushov, ML Bychkov… - Biochemistry …, 2017 - Springer
The discovery in higher animals of proteins from the Ly6/uPAR family, which have structural
homology with snake “three-finger” neurotoxins, has generated great interest in these …
homology with snake “three-finger” neurotoxins, has generated great interest in these …
Human secreted proteins SLURP‐1 and SLURP‐2 control the growth of epithelial cancer cells via interactions with nicotinic acetylcholine receptors
EN Lyukmanova, ML Bychkov… - British Journal of …, 2018 - Wiley Online Library
Background and Purpose Nicotinic acetylcholine receptors (nAChRs) are a promising target
for development of new anticancer therapies. Here we have investigated the effects of the …
for development of new anticancer therapies. Here we have investigated the effects of the …
Structural insight into specificity of interactions between nonconventional three-finger weak toxin from Naja kaouthia (WTX) and muscarinic acetylcholine receptors
EN Lyukmanova, ZO Shenkarev, MA Shulepko… - Journal of Biological …, 2015 - ASBMB
Weak toxin from Naja kaouthia (WTX) belongs to the group of nonconventional" three-finger"
snake neurotoxins. It irreversibly inhibits nicotinic acetylcholine receptors and allosterically …
snake neurotoxins. It irreversibly inhibits nicotinic acetylcholine receptors and allosterically …
Water-soluble variant of human Lynx1 induces cell cycle arrest and apoptosis in lung cancer cells via modulation of α7 nicotinic acetylcholine receptors
M Bychkov, Z Shenkarev, M Shulepko, O Shlepova… - PLoS …, 2019 - journals.plos.org
Lynx1 is the first three-finger prototoxin found in the mammalian central nervous system. It is
a GPI-anchored protein modulating nicotinic acetylcholine receptors (nAChRs) in the brain …
a GPI-anchored protein modulating nicotinic acetylcholine receptors (nAChRs) in the brain …