[HTML][HTML] The Strongyloides bioassay toolbox: a unique opportunity to accelerate functional biology for nematode parasites
LC Cadd, B Crooks, NJ Marks, AG Maule… - Molecular and …, 2022 - Elsevier
Caenorhabditis elegans is a uniquely powerful tool to aid understanding of fundamental
nematode biology. While C. elegans boasts an unrivalled array of functional genomics tools …
nematode biology. While C. elegans boasts an unrivalled array of functional genomics tools …
Foldamers reveal and validate therapeutic targets associated with toxic α-synuclein self-assembly
Parkinson's disease (PD) is a progressive neurodegenerative disorder for which there is no
successful prevention or intervention. The pathological hallmark for PD involves the self …
successful prevention or intervention. The pathological hallmark for PD involves the self …
Simple models to understand complex disease: 10 years of progress from Caenorhabditis elegans models of amyotrophic lateral sclerosis and frontotemporal lobar …
RJ Eck, JG Stair, BC Kraemer… - Frontiers in Neuroscience, 2024 - frontiersin.org
The nematode Caenorhabditis elegans are a powerful model system to study human
disease, with numerous experimental advantages including significant genetic and cellular …
disease, with numerous experimental advantages including significant genetic and cellular …
Protein mimetic 2D FAST rescues alpha synuclein aggregation mediated early and post disease Parkinson's phenotypes
NH Stillman, JA Joseph, J Ahmed, CZ Baysah… - Nature …, 2024 - nature.com
Abberent protein-protein interactions potentiate many diseases and one example is the
toxic, self-assembly of α-Synuclein in the dopaminergic neurons of patients with Parkinson's …
toxic, self-assembly of α-Synuclein in the dopaminergic neurons of patients with Parkinson's …
“Common-Precursor” Protein Mimetic Approach to Rescue Aβ Aggregation-Mediated Alzheimer's Phenotypes
RA Dohoney, JA Joseph, C Baysah… - ACS Chemical …, 2023 - ACS Publications
Abberent protein–protein interactions (aPPIs) are associated with an array of pathological
conditions, which make them important therapeutic targets. The aPPIs are mediated via …
conditions, which make them important therapeutic targets. The aPPIs are mediated via …
A 2D Fragment-Assisted Protein Mimetic Approach to Rescue α-Synuclein Aggregation Mediated Early and Post-Disease Parkinson's Phenotypes
NH Stillman, JA Joseph, J Ahmed, RA Dohoney… - bioRxiv, 2022 - biorxiv.org
We have developed a Oligopyridylamide (OP) based 2-Dimensional Fragment-Assisted
Structure-based Technique (2D-FAST) to identify potent antagonists of α-Synuclein (αS) …
Structure-based Technique (2D-FAST) to identify potent antagonists of α-Synuclein (αS) …
Semi Automated Movement Based Screening of Aqueous Extracts of Cinnamon Leaf, Almond, Beetroot Carrot, Ashwagandha and Tulsi on Caenorhabditis Elegans …
A Patil, S Yerri, U Nidoni - … of Environment and …, 2023 - research.send4journal.com
The research was conducted at University of Agricultural Sciences Raichur during 2021-22.
In this research Caenorhabditis elegans is utilized by the researchers to know the effects of …
In this research Caenorhabditis elegans is utilized by the researchers to know the effects of …
A 2D Fragment-Assisted Protein Mimetic Approach to Rescue α-Synuclein Aggregation Mediated Early and Post-Disease Parkinson's Phenotypes
S Kumar, N Stillman, J Joseph, J Ahmed, R Dohoney… - 2022 - researchsquare.com
We have developed a Oligopyridylamide (OP) based 2-Dimensional Fragment-Assisted
Structure-based Technique (2D-FAST) to identify potent antagonists of α-Synuclein (αS) …
Structure-based Technique (2D-FAST) to identify potent antagonists of α-Synuclein (αS) …
Inhibition of de novo and the Prion-Like Spread of Amyloidogenesis Using in vitro and in vivo Disease Models
JA Joseph - 2022 - search.proquest.com
The aberrant fibrous, extracellular, and intracellular proteinaceous deposits in cells, organs
and tissues are referred to as amyloids. These deposits are dominated by β-sheet structures …
and tissues are referred to as amyloids. These deposits are dominated by β-sheet structures …
[PDF][PDF] Inhibition of Amyloid Aggregates in C. Elegans as a Model for Treatment of Alzheimer's and Parkinson's
A Thomas - give.du.edu
Parkinson's Disease (PD) and Alzheimer's Disease (AD) are neurodegenerative diseases
characterized by pathogenic amyloid aggregates that lead to loss of brain function, which …
characterized by pathogenic amyloid aggregates that lead to loss of brain function, which …