Lysosomes serve as the cellular recycling centre and are filled with numerous hydrolases
that can degrade most cellular macromolecules. Lysosomal membrane permeabilization …

Lipid metabolism is regulated by multiple signaling pathways, and generates a variety of
bioactive lipid molecules. These bioactive lipid molecules known as signaling molecules …

Among the caspases that cause regulated cell death, a unique function for caspase-7 has
remained elusive. Caspase-3 performs apoptosis, whereas caspase-7 is typically …

Lysosomes are the key degradative compartments of the cell. Lysosomal cathepsins, which
are enclosed in the lysosomes, help to maintain the homeostasis of the cell's metabolism by …

Nonalcoholic fatty liver disease (NAFLD) is a chronic disease with a histological spectrum
ranging from steatosis alone, to nonalcoholic steatohepatitis (NASH). The latter is …

Unconventional protein secretion (UPS) allows the release of specific leaderless proteins
independently of the classical endoplasmic reticulum (ER)-Golgi secretory pathway. While it …

Disturbances of lipid homeostasis in cells provoke human diseases. The elucidation of the
underlying mechanisms and the development of efficient therapies represent formidable …

Skin lipids, compose of sebocyte-, keratinocyte-, and microbe-derived lipids, dramatically
influence skin status by different mechanisms.(I) Physical chemistry function: They are …

Acid sphingomyelinase (ASM), a key enzyme in sphingolipid metabolism, hydrolyzes
sphingomyelin to ceramide and phosphorylcholine. In mammals, the expression of a single …

Amitriptyline, a tricyclic antidepressant, has been used in the clinic to treat a number of
disorders, in particular major depression and neuropathic pain. In the 1970s the ability of …