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Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes
in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and …

Background The function of the thymus in human adults is unclear, and routine removal of
the thymus is performed in a variety of surgical procedures. We hypothesized that the adult …

Extensive, large-scale single-cell profiling of healthy human blood at different ages is one of
the critical pending tasks required to establish a framework for the systematic understanding …

There is a dramatic remodeling of the T cell compartment during aging. The most notorious
changes are the reduction of the naive T cell pool and the accumulation of memory-like T …

Abstract Profiling the T-Cell Receptor (TCR) repertoire is establishing as a potent approach
to investigate autologous and treatment-induced antitumor immune response. Technical and …

Hematopoietic stem cells (HSCs) support haematopoiesis throughout life and give rise to the
whole variety of cells of the immune system. Developing in the early embryo, passing …

Despite mRNA vaccination, elderly individuals remain especially vulnerable to severe
consequences of SARS-CoV-2 infection. Here, we compare the memory B cell responses in …

The evolution of T cell molecular signatures in the distal lung of patients with severe
pneumonia is understudied. Here, we analyzed T cell subsets in longitudinal …

Aging is a complex journey shaped by interactions among mechanisms, biochemistry,
physiology, and social habits. This review explores aging's core facets by uncovering the …