Tartrazine belongs to the colors raising significant concerns regarding consumer safety at
low doses relevant for real-life human exposure. Scientific literature continues to grow after …

Malachite green (MG) is a synthetic dye that uses ranges from its application as a tissue dye
to that as an antiparasitic in aquaculture. Several studies have reported the presence of this …

Biomarker-driven drug selection plays a central role in cancer drug discovery and
development, and in diagnostic strategies to improve the use of traditional chemotherapeutic …

Hydroxyurea (HU) plays an important role in the treatment of patients with sickle cell disease
(SCD). Although HU has been associated with an increased risk of leukemia in some …

Genotoxicity studies in coastal ecosystems have been a priority in Environmental Risk
Assessment (ERA). This research aimed to study the genotoxicity by the micronucleus test …

Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential base excision repair enzyme
that is upregulated in a number of cancers, contributes to resistance of tumors treated with …

Environmental enrichment (EE) has a neuroprotective role and prevents the development of
cocaine addiction behavior in rats. Studies showing the role of EE in cocaine toxicity are …

Hydroxyurea (HU) is the primary pharmacologic agent for preventing the complications and
improving the quality of life of sickle cell anemia (SCA) patients. Although HU has been …

Chromosome aberration assays are employed to detect the induction of chromosome
breakage (clastogenesis) in somatic and germ cells by direct observation of the …

Ethyl methanesulfonate (EMS) was evaluated as part of the validation effort for the rat Pig‐a
mutation assay and compared with other well‐established in vivo genotoxicity endpoints …