Sepsis is a life-threatening clinical syndrome characterized by multiorgan dysfunction
caused by a dysregulated or over-reactive host response to infection. During sepsis, the …

Disseminated intravascular coagulation (DIC) is an acquired clinicobiological syndrome
characterized by widespread activation of coagulation leading to fibrin deposition in the …

Disseminated intravascular coagulation is a frequent complication of sepsis. Coagulation
activation, inhibition of fibrinolysis, and consumption of coagulation inhibitors lead to a …

Appropriate activation of coagulation requires a balance between procoagulant and
anticoagulant proteins in blood. Loss in this balance leads to hemorrhage and thrombosis. A …

Antithrombin (AT) is a plasma-derived, single-chain glycoprotein with a molecular weight of
58 kDa. It is a serine protease inhibitor (serpin), sharing about 30% homology in amino acid …

Sepsis is a clinical syndrome that results from a systemic host response to an infection. The
outcome of sepsis is poor, and mortality rates are as high as 30–40%. Sepsis is associated …

Background Critical illness is associated with uncontrolled inflammation and vascular
damage which can result in multiple organ failure and death. Antithrombin III (AT III) is an …

Life-threatening complications from bacterial infections are a major and growing clinical
problem, aggravated by the emergence and spread of antibiotic resistance in bacterial …

The serpin antithrombin III (AT III), the most important natural inhibitor of thrombin activity,
has been shown to exert marked anti-inflammatory properties and proven to be efficacious …

Disseminated intravascular coagulation (DIC) is a disorder characterized by both acute
generalized, widespread activation of coagulation, which results in thrombotic complications …