CREB nuclear transcription activity as a targeting factor in the treatment of diabetes and diabetes complications

K Benchoula, IS Parhar, P Madhavan… - Biochemical Pharmacology, 2021 - Elsevier
Diabetes mellitus is a metabolic disorder diagnosed by elevated blood glucose levels and a
defect in insulin production. Blood glucose, an energy source in the body, is regenerated by …

Tremendous fidelity of vitamin D3 in age-related neurological disorders

M Skv, SM Abraham, O Eshwari, K Golla… - Molecular …, 2024 - Springer
Vitamin D3 (VD) is a secosteroid hormone and shows a pleiotropic effect in brain-related
disorders where it regulates redox imbalance, inflammation, apoptosis, energy production …

Vitamin D3 administration prevents memory deficit and alteration of biochemical parameters induced by unpredictable chronic mild stress in rats

H Bakhtiari-Dovvombaygi, S Izadi, M Zare… - Scientific Reports, 2021 - nature.com
The present study aimed to investigate the effects of vitamin D3 (Vit D) administration on
memory function, hippocampal level of amyloid-beta (Aβ), brain-derived neurotrophic factor …

Investigating the effect of crocin on memory deficits induced by total sleep deprivation (TSD) with respect to the BDNF, TrkB and ERK levels in the hippocampus of …

M Looti Bashiyan, M Nasehi… - Journal of …, 2021 - journals.sagepub.com
Background: Sleep deprivation (SD) induces cognitive impairments such as memory deficit.
Brain-derived neurotrophic factor (BDNF) is considered as the most critical neurotrophin in …

Umbelliferone ameliorates memory impairment and enhances hippocampal synaptic plasticity in scopolamine-induced rat model

GY Choi, HB Kim, JM Cho, I Sreelatha, IS Lee… - Nutrients, 2023 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder, characterized by memory loss
and cognitive decline. Among the suggested pathogenic mechanisms of AD, the cholinergic …

Synergistic Anti-inflammatory and Neuroprotective Effects of Cinnamomum cassia and Zingiber officinale Alleviate Diabetes-Induced Hippocampal Changes in Male …

HM ALmohaimeed, ZM Mohammedsaleh… - Frontiers in Cell and …, 2021 - frontiersin.org
Background: Depression has been reported as a common comorbidity in diabetes mellitus
although the underlying mechanism responsible for this is not well known. Although both …

Calcitriol supplementation attenuates cisplatin-induced behavioral and cognitive impairments through up-regulation of BDNF in male rats

H Panahpour, S Ghaheri, H Saadati - Brain Research Bulletin, 2022 - Elsevier
Chemotherapy-induced cognitive impairment such as memory impairment and
concentration problems are now extensively recognized as side effects of chemotherapy …

Restorative action of vitamin D3 on motor dysfunction through enhancement of neurotrophins and antioxidant expression in the striatum

SKV Manjari, S Maity, R Poornima, SY Yau, K Vaishali… - Neuroscience, 2022 - Elsevier
A number of studies has explored a positive correlation between low levels of serum Vitamin
D 3 (VD; cholecalciferol) and development of neurodegenerative diseases including …

Flavonols as a Potential Pharmacological Intervention for Alleviating Cognitive Decline in Diabetes: Evidence from Preclinical Studies

A Horvat, I Vlašić, J Štefulj, N Oršolić… - Life, 2023 - mdpi.com
Diabetes mellitus is a complex metabolic disease associated with reduced synaptic
plasticity, atrophy of the hippocampus, and cognitive decline. Cognitive impairment results …

Correlation between vitamin D and serum brain derived neurotropic factor levels in type 2 diabetes mellitus patients

M Alqudah, M Khanfar, MA Alfaqih… - Biomedical …, 2022 - spandidos-publications.com
Diabetes Mellitus (DM) currently ranks as the most common endocrine disorder worldwide.
Current opinion views DM as a group of heterogeneous metabolic diseases characterized …