In recent years, the biopharmaceutical industry's interest in gene therapy modalities has
increased dramatically. To warrant their quality during manufacturing and …

Gene therapy is a promising therapeutic approach for genetic and acquired diseases
nowadays. Among DNA delivery vectors, recombinant adeno‐associated virus (rAAV) is one …

Controlled assembly of a protein shell around a viral genome is a key step in the life cycle of
many viruses. Here we report a strategy for regulating the co-assembly of nonviral proteins …

Adeno-associated virus (AAV) vector has become the leading platform for gene delivery.
Each serotype exhibits a different tissue tropism, immunogenicity, and in vivo transduction …

The last few years have seen a rise in the identification and development of bio-therapeutics
through the use of cutting-edge delivery methods or bio-formulations, which has created bio …

Adeno‐associated viruses (AAV) are widely used viral vectors for in vivo gene therapy. The
purification of AAV, particularly the separation of genome‐containing from empty AAV …

Adeno-associated viral vectors (AAVs) are the predominant viral vectors used for gene
therapy applications. A significant challenge in obtaining effective doses is removing non …

The proportion of full and empty capsids represents a critical quality attribute of adeno-
associated virus (AAV)-based therapeutics. In this study, pH-gradient anion exchange …

Cell and gene therapy (CGT) is a field of therapeutic medicine that aims to treat, prevent,
and cure diseases using engineered cells (stem cells, immune cells, and differentiated adult …

The recent FDA approval of several adeno-associated virus (AAV)-based gene therapies is
driving demand for AAV production. One of the biggest AAV manufacturing challenges is …