Lung cancer continues to be the leading cause of cancer-related death worldwide. In the last
decade, significant advancements in the diagnosis and treatment of lung cancer, particularly …

The success of anticancer therapy is usually limited by the development of drug resistance.
Such acquired resistance is driven, in part, by intratumoural heterogeneity—that is, the …

Metastasis in lung cancer is a multifaceted process. In this review, we will dissect the
process in several isolated steps such as angiogenesis, hypoxia, circulation, and …

Despite advances in treatment, lung cancer survival rates remain low. A better
understanding of the cellular heterogeneity and interplay of cancer-associated fibroblasts …

The high metabolic rate of tumours often leads to acidosis and hypoxia in poorly perfused
regions. Tumour cells have thus evolved the ability to function in a more acidic environment …

Growing evidence for intratumour heterogeneity informs us that single-site biopsies fall short
of revealing the complete genomic landscape of a tumour. With an expanding repertoire of …

Despite a continuing debate about the existence of cancer stem cells (CSCs), recent
discoveries have provided further support for their existence and their roles in drug …

Periostin (POSTN), a member of the matricellular protein family, is a secreted adhesion-
related protein produced in the periosteum and periodontal ligaments. Matricellular proteins …

Lung cancer is the leading cause of cancer-related death in men and women in the United
States, accounting for approximately 28% of total cancer deaths in 2010 despite comprising …

The tumor microenvironment is one of the important drivers of tumor development. Cancer-
associated fibroblasts (CAFs) are a major component of the tumor stroma and actively …