Neutrophil extracellular trap (NETosis), the web-like structures induced by neutrophil death,
is an important inflammatory mechanism of the immune system leading to reactive oxygen …

Cardiovascular and renal diseases are among the leading causes of death worldwide, and
regardless of current efforts, there is a demanding need for therapeutic alternatives to …

Background: Acute kidney injury (AKI) is a serious clinical problem associated with high
morbidity and mortality worldwide. The pathophysiology and pathogenesis of AKI is complex …

Ischemia/reperfusion (I/R)-induced endothelial dysfunction occurs in various cardiovascular
disorders. I/R injury is partially driven by the release of cytokines. Known for its use in …

Neutrophils are the most abundant leukocytes in the blood. They are rapidly mobilized from
the circulation to sites of inflammation and/or infection. In affected tissues, neutrophils exhibit …

Extracellular histones are crucial damage-associated molecular patterns involved in the
development and progression of multiple critical and inflammatory diseases, such as sepsis …

The aim of this study is to investigate the effect of propolis, which may have estrogenic
effects, on myocardial ischemia/reperfusion (mI/R) injury not only in male rats but also in …

Background Cardiorenal syndrome (CRS) type 4 is prevalent among the chronic kidney
disease (CKD) population, with many patients dying from cardiovascular complications …

Background Before implementing individualized strategies to treat acute kidney injury (AKI),
identifying clusters of patients with divergent pathophysiological mechanisms, diagnosis …

组蛋白是染色质结构蛋白, 也参与调节真核细胞基因表达. 一旦发生大量细胞死亡,
组蛋白会释放至细胞外成为胞外组蛋白或进入血液成为循环组蛋白, 成为损伤相关分子模式 …