Polyphosphate kinase 2 (PPK2) enzymes: structure, function, and roles in bacterial physiology and virulence

N Neville, N Roberge, Z Jia - International journal of molecular sciences, 2022 - mdpi.com
Inorganic polyphosphate (polyP) has been implicated in an astonishing array of biological
functions, ranging from phosphorus storage to molecular chaperone activity to bacterial …

Recent developments and challenges for the industrial implementation of polyphosphate kinases

M Tavanti, J Hosford, RC Lloyd, MJB Brown - ChemCatChem, 2021 - Wiley Online Library
Polyphosphate kinases (PPKs) have emerged as valuable candidates to address the unmet
need for scalable recycling of the common enzyme cofactor adenosine‐5'‐triphosphate …

Engineering sulfonate group donor regeneration systems to boost biosynthesis of sulfated compounds

R Xu, W Zhang, X Xi, J Chen, Y Wang, G Du… - Nature …, 2023 - nature.com
Sulfonation as one of the most important modification reactions in nature is essential for
many biological macromolecules to function. Development of green sulfonate group donor …

Discovery, characterization and engineering of ligases for amide synthesis

M Winn, M Rowlinson, F Wang, L Bering, D Francis… - Nature, 2021 - nature.com
Coronatine and related bacterial phytotoxins are mimics of the hormone jasmonyl-l-
isoleucine (JA-Ile), which mediates physiologically important plant signalling pathways …

One-pot biocatalytic transformation of adipic acid to 6-aminocaproic acid and 1, 6-hexamethylenediamine using carboxylic acid reductases and transaminases

TP Fedorchuk, AN Khusnutdinova… - Journal of the …, 2019 - ACS Publications
Production of platform chemicals from renewable feedstocks is becoming increasingly
important due to concerns on environmental contamination, climate change, and depletion …

Thioester-mediated biocatalytic amide bond synthesis with in situ thiol recycling

C Schnepel, LR Pérez, Y Yu, A Angelastro, RS Heath… - Nature Catalysis, 2023 - nature.com
The activation of carboxylic acids to thioesters plays an important role in biology. However,
biochemical studies and biotechnological applications are hampered by a general lack of …

One‐step biocatalytic synthesis of sustainable surfactants by selective amide bond formation

M Lubberink, W Finnigan, C Schnepel… - Angewandte Chemie …, 2022 - Wiley Online Library
Abstract N‐alkanoyl‐N‐methylglucamides (MEGAs) are non‐toxic surfactants widely used
as commercial ingredients, but more sustainable syntheses towards these compounds are …

ATP regeneration by a single polyphosphate kinase powers multigram-scale aldehyde synthesis in vitro

M Tavanti, J Hosford, RC Lloyd, MJB Brown - Green Chemistry, 2021 - pubs.rsc.org
ATP recycling systems are required to avoid the addition of stoichiometric quantities of
cofactor and facilitate industrial implementation of ATP-dependent enzymes. One factor that …

Biocatalytic monoacylation of symmetrical diamines and its application to the synthesis of pharmaceutically relevant amides

M Lubberink, C Schnepel, J Citoler, SR Derrington… - ACS …, 2020 - ACS Publications
Monoacylated diamines are common motifs present in pharmaceuticals, agrochemicals, and
natural products. However, the synthesis of these compounds often requires selective …

A bicyclic S-adenosylmethionine regeneration system applicable with different nucleosides or nucleotides as cofactor building blocks

D Popadić, D Mhaindarkar, MHND Thai… - RSC Chemical …, 2021 - pubs.rsc.org
The ubiquitous cofactor S-adenosyl-L-methionine (SAM) is part of numerous biochemical
reactions in metabolism, epigenetics, and cancer development. As methylation usually …