The accurate transition from G1 phase of the cell cycle to S phase is crucial for the control of
eukaryotic cell proliferation, and its misregulation promotes oncogenesis. During G1 phase …

Nearly 20% of the budding yeast genome is transcribed periodically during the cell division
cycle. The precise temporal execution of this large transcriptional program is controlled by a …

Highlights•Recurring motifs are found in eukaryotic cell cycle regulation.•These include
positive and negative feedbacks and reciprocal regulation.•We review examples of all of …

Reprogramming gene expression is crucial for DNA replication stress response. We used
quantitative proteomics to establish how the transcriptional response results in changes in …

The conserved family of Cdc14 phosphatases targets cyclin-dependent kinase substrates in
yeast, mediating late mitotic signaling events. To discover substrates and regulators of the …

Background Cluster analysis is an integral part of precision medicine and systems biology,
used to define groups of patients or biomolecules. Consensus clustering is an ensemble …

The function of transcription in dynamic gene expression programs has been extensively
studied, but little is known about how it is integrated with RNA turnover at the genome‐wide …

The centromere is a specialized chromosomal structure essential for chromosome
segregation. Centromere dysfunction leads to chromosome segregation errors and genome …

In the fission yeast Schizosaccharomyces pombe, the transcriptional-regulatory network that
governs flocculation remains poorly understood. Here, we systematically screened an array …

When DNA replication is challenged cells activate a DNA synthesis checkpoint, blocking cell
cycle progression until they are able to overcome the replication defects. In fission yeast …