TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases

M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

[HTML][HTML] Mammalian transient receptor potential TRPA1 channels: from structure to disease

K Talavera, JB Startek, J Alvarez-Collazo… - Physiological …, 2020 - journals.physiology.org
The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Involvement of neural transient receptor potential channels in peripheral inflammation

HA Silverman, A Chen, NL Kravatz… - Frontiers in …, 2020 - frontiersin.org
Transient receptor potential (TRP) channels are a superfamily of non-selective cation
channels that act as polymodal sensors in many tissues throughout mammalian organisms …

Cannabidiol and other non-psychoactive cannabinoids for prevention and treatment of gastrointestinal disorders: useful nutraceuticals?

V Martínez, A Iriondo De-Hond, F Borrelli… - International Journal of …, 2020 - mdpi.com
Cannabis sativa is an aromatic annual flowering plant with several botanical varieties, used
for different purposes, like the production of fibers, the production of oil from the seeds, and …

TRPA1 channels: molecular sentinels of cellular stress and tissue damage

F Viana - The Journal of physiology, 2016 - Wiley Online Library
TRPA1 is a non‐selective cation channel expressed in mammalian peripheral pain
receptors, with a major role in chemonociception. TRPA1 has also been implicated in …

What is the evidence for the role of TRP channels in inflammatory and immune cells?

A Parenti, F De Logu, P Geppetti… - British journal of …, 2016 - Wiley Online Library
A complex network of many interacting mechanisms orchestrates immune and inflammatory
responses. Among these, the cation channels of the transient receptor potential (TRP) family …

New insights on the role of TRP channels in calcium signalling and immunomodulation: review of pathways and implications for clinical practice

S Froghi, CR Grant, R Tandon, A Quaglia… - Clinical reviews in …, 2021 - Springer
Calcium is the most abundant mineral in the human body and is central to many
physiological processes, including immune system activation and maintenance. Studies …

Functional role of transient receptor potential channels in immune cells and epithelia

M Khalil, K Alliger, C Weidinger, C Yerinde… - Frontiers in …, 2018 - frontiersin.org
Transient receptor potential (TRP) ion channels are widely expressed in several tissues
throughout the mammalian organism. Originally, TRP channel physiology was focusing on …

The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1

S Bertin, Y Aoki-Nonaka, J Lee, PR De Jong, P Kim… - Gut, 2017 - gut.bmj.com
Objective Transient receptor potential ankyrin-1 (TRPA1) and transient receptor potential
vanilloid-1 (TRPV1) are calcium (Ca2+)-permeable ion channels mostly known as pain …

TRPA1 role in inflammatory disorders: what is known so far?

L Landini, D Souza Monteiro de Araujo, M Titiz… - International Journal of …, 2022 - mdpi.com
The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of
channels, is primarily localized in a subpopulation of primary sensory neurons of the …