This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …

This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …

In this work we advance the hypothesis that omega-3 (ω-3) long-chain polyunsaturated fatty
acids (LCPUFAs) exhibit cytoprotective and cytotherapeutic actions contributing to a number …

Aerobic life on our planet relies on the use of molecular oxygen for energy as well as for
biosynthesis of important biological compounds in metabolic pathways. Thermodynamically …

Aberrant arachidonic acid metabolism is involved in the inflammatory and carcinogenic
processes. In this study, we investigated the effects of curcumin, a naturally occurring …

Celastrol, a quinone methide triterpene derived from the medicinal plant Tripterygium
wilfordii, has been used to treat chronic inflammatory and autoimmune diseases, but its …

Glucose, as the main consuming nutrient of the body, faces different destinies in cancer
cells. Glycolysis, oxidative phosphorylation, and pentose phosphate pathways produce …

The cysteinyl leukotrienes (CysLTs) are a family of potent inflammatory lipid mediators
synthesized from arachidonic acid by a variety of cells including mast cells, eosinophils …

Background & Aims: Overexpression of cyclooxygenase-2 (COX-2) is implicated in many
steps of cancer development. Single nucleotide polymorphisms (SNPs) in the COX-2 …

Osteoarthritis is an inflammatory disease of load-bearing synovial joints that is currently
treated with drugs that exhibit numerous side effects and are only temporarily effective on …