Increased understanding of the biology of interleukin 17 (IL-17) has revealed that this
cytokine is a central player in immunity at the sites most exposed to microorganisms …

Although the pathogenic mechanisms underlying axial spondyloarthritis (axSpA) and
psoriatic arthritis (PsA) are not fully elucidated, several lines of evidence suggest that …

Germline loss-of-function mutations in the transcription factor signal transducer and activator
of transcription 3 (STAT3) cause immunodeficiency, whereas somatic gain-of-function …

Th17 cell differentiation and pathogenicity depend on metabolic reprogramming inducing
shifts toward glycolysis. Here, we show that the pyruvate kinase M2 (PKM2), a glycolytic …

Invasive Staphylococcus aureus infections are a leading cause of morbidity and mortality in
both hospital and community settings, especially with the widespread emergence of virulent …

The induction and action of type I interferon (IFN) is of fundamental importance in human
immune defenses toward microbial pathogens, particularly viruses. Basic discoveries within …

Chronic mucocutaneous candidiasis disease (CMCD) may be caused by autosomal
dominant (AD) IL-17F deficiency or autosomal recessive (AR) IL-17RA deficiency. Here …

CD4+ T helper (Th) cells play a central role in the adaptive immune response by providing
help to B cells and cytotoxic T cells and by releasing different types of cytokines in tissues to …

Foxp3+ regulatory T cells (Tregs) play essential roles in maintaining the immune balance.
Although the majority of Tregs are formed in the thymus, increasing evidence suggests that …

Skeletal deformities are typical AD-HIES manifestations, which are mainly caused by
heterozygous and loss-of-function mutations in Signal transducer and activator of …