Chronic hypoxic exposure induces changes in the structure of pulmonary arteries, as well as
in the biochemical and functional phenotypes of each of the vascular cell types, from the …

Obstructive sleep apnea (OSA) has emerged as a major public health problem and
increasing evidence indicates that untreated OSA can lead to the development of various …

Safety concerns with erythropoietin analogues and intravenous (IV) iron for treatment of
anemia in CKD necessitate development of safer therapies. Roxadustat (FG-4592) is an …

Rationale: Chronic hypoxia induces pulmonary vascular remodeling, pulmonary
hypertension, and right ventricular hypertrophy. At present, little is known about mechanisms …

Study objectives Obstructive sleep apnea (OSA) and hypertension are independently
associated with increased stiffness of large arteries that may contribute to left ventricular (LV) …

Calpain is an intracellular Ca2D-dependent cysteine protease (EC 3.4. 22.17; Clan CA,
family C02) discovered in 1964. It was also called CANP (Ca2D-activated neutral protease) …

Elucidating the molecular genetic basis of adaptive traits is a central goal of evolutionary
genetics. The cold, hypoxic conditions of high-altitude habitats impose severe metabolic …

Sleep-disordered breathing, and particularly the highly prevalent obstructive sleep apnea
syndrome, is a multicomponent disorder combining intermittent hypoxia (IH), sleep …

Hypoxia-induced cell injury has been related to multiple pathological conditions. In order to
render hypoxia-sensitive cells and tissues resistant to low O2 environment, in this current …

Through long-term laboratory selection (over 200 generations), we have generated
Drosophila melanogaster populations that tolerate severe, normally lethal, levels of hypoxia …