In the absence of contemporary, population-based epidemiological studies, estimates of the
incidence and prevalence of the inherited cardiomyopathies have been derived from …

Sodium glucose cotransporter 2 inhibitors (SGLT2i) constitute a promising drug treatment for
heart failure patients with either preserved or reduced ejection fraction. Whereas SGLT2i …

Background: SGLT2 (sodium/glucose cotransporter 2) inhibitors exert robust
cardioprotective effects against heart failure in patients with diabetes, and there is intense …

SCN5A gene encodes the pore-forming ion-conducting α-subunit of the cardiac sodium
channel (Nav1. 5), which is responsible for the initiation and propagation of action potentials …

The gene SCN5A encodes the main cardiac sodium channel Na V 1.5. This channel
predominates the cardiac sodium current, I Na, which underlies the fast upstroke of the …

The SCN5A gene encodes the alpha subunit of the main cardiac sodium channel Nav1. 5.
This channel predominates inward sodium current (INa) and plays a critical role in …

Brugada syndrome is a heritable channelopathy characterized by a peculiar
electrocardiogram (ECG) pattern and increased risk of cardiac arrhythmias and sudden …

The term dilated cardiomyopathy (DCM) defines a heterogeneous group of cardiac
disorders, which are characterized by left ventricular or biventricular dilatation and systolic …

Influx of sodium ions through voltage-gated sodium channels in cardiomyocytes is essential
for proper electrical conduction within the heart. Both acquired conditions associated with …

Life threatening ventricular arrhythmias leading to sudden cardiac death are a major cause
of morbidity and mortality. In the absence of structural heart disease, these arrhythmias …