Cerebellar and afferent ataxias present with a characteristic gait disorder that reflects
cerebellar motor dysfunction and sensory loss. These disorders are a diagnostic challenge …

Increasingly, cerebellar syndromes are recognized as affecting multiple systems.
Extracerebellar features include peripheral neuropathies affecting proprioception; cranial …

Background Neuroinflammation is proposed to accompany, or even contribute to,
neuropathology in Friedreich ataxia (FRDA), with implications for disease treatment and …

Background Spinal cord damage is a hallmark of Friedreich's ataxia (FRDA), but its
progression and clinical correlates remain unclear. Objective The objective of this study was …

Introduction Drug development for neurodegenerative diseases such as Friedreich's ataxia
(FRDA) is limited by a lack of validated, sensitive biomarkers of pharmacodynamic response …

Friedreich ataxia is a progressive neurodegenerative disorder characterized by cerebellar
and spinal atrophy. However, studies to elucidate the longitudinal progression of the …

Friedreich ataxia (FRDA) is a rare, inherited neurodegenerative disease characterised in
most cases by progressive and debilitating motor dysfunction. Degeneration of cerebellar …

Multiple lines of research provide compelling evidence for a role of the cerebellum in a wide
array of cognitive and affective functions, going far beyond its historical association with …

The ever‐increasing body of ataxia research provides opportunities for large‐scale meta‐
analyses, systematic reviews, and data aggregation. Because multiple standardized scales …

Objective Friedreich ataxia (FRDA) is an inherited condition caused by a GAA triplet repeat
(GAA‐TR) expansion in the FXN gene. Clinical features of FRDA include ataxia …