Resolution of inflammation: a new therapeutic frontier

JN Fullerton, DW Gilroy - Nature reviews Drug discovery, 2016 - nature.com
Dysregulated inflammation is a central pathological process in diverse disease states.
Traditionally, therapeutic approaches have sought to modulate the pro-or anti-inflammatory …

Mammalian lipoxygenases and their biological relevance

H Kuhn, S Banthiya, K Van Leyen - … Acta (BBA)-Molecular and Cell Biology …, 2015 - Elsevier
Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which
have been implicated not only in cell proliferation and differentiation but also in the …

Phenol-soluble modulins and staphylococcal infection

A Peschel, M Otto - Nature Reviews Microbiology, 2013 - nature.com
Staphylococcus aureus is an important human pathogen and a leading cause of death
worldwide. Phenol-soluble modulins (PSMs) have recently emerged as a novel toxin family …

NSAIDs and cancer resolution: new paradigms beyond cyclooxygenase

OR Kolawole, K Kashfi - International journal of molecular sciences, 2022 - mdpi.com
Acute inflammation or resolved inflammation is an adaptive host defense mechanism and is
self-limiting, which returns the body to a state of homeostasis. However, unresolved …

[HTML][HTML] Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents

J Dalli, JW Winkler, RA Colas, H Arnardottir… - Chemistry & biology, 2013 - cell.com
Resolvins are a family of n-3 lipid mediators initially identified in resolving inflammatory
exudates that temper inflammatory responses to promote catabasis. Here, temporal …

Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15)

I Ivanov, H Kuhn, D Heydeck - Gene, 2015 - Elsevier
Lipoxygenases (LOX) form a family of lipid peroxidizing enzymes, which have been
implicated in a number of physiological processes and in the pathogenesis of inflammatory …

The inflammasome in host response to biomaterials: Bridging inflammation and tissue regeneration

DP Vasconcelos, AP Águas, MA Barbosa, P Pelegrín… - Acta biomaterialia, 2019 - Elsevier
The development of new biomaterials to be used in tissue engineering applications is
creating new solutions for a range of healthcare problems. The trend in biomaterials …

Anti-angiogenic treatment strategies for the therapy of endometriosis

MW Laschke, MD Menger - Human reproduction update, 2012 - academic.oup.com
BACKGROUND Angiogenesis, ie the development of new blood vessels from pre-existing
ones, represents an integral part in the pathogenesis of endometriosis. During the last …

[HTML][HTML] Therapeutic potential of pro-resolving mediators in diabetic kidney disease

T Vartak, C Godson, E Brennan - Advanced drug delivery reviews, 2021 - Elsevier
Renal microvascular disease associated with diabetes [Diabetic kidney disease-DKD] is the
leading cause of chronic kidney disease. In DKD, glomerular basement membrane …

Pro-resolving lipid mediators (SPMs) and their actions in regulating miRNA in novel resolution circuits in inflammation

A Recchiuti, CN Serhan - Frontiers in immunology, 2012 - frontiersin.org
Unresolved inflammation is associated with several widely occurring diseases such as
arthritis, periodontal diseases, cancer, and atherosclerosis. Endogenous mechanisms that …