Genetics of type 2 diabetes—pitfalls and possibilities

RB Prasad, L Groop - Genes, 2015 - mdpi.com
Type 2 diabetes (T2D) is a complex disease that is caused by a complex interplay between
genetic, epigenetic and environmental factors. While the major environmental factors, diet …

Latent autoimmune diabetes in adults

RG Naik, BM Brooks-Worrell… - The Journal of Clinical …, 2009 - academic.oup.com
Context: Autoantibodies that are reactive to islet antigens are present at the time of
diagnosis in most patients with type 1 diabetes. Additionally, approximately 10% of …

Risk of cancer following hospitalization for type 2 diabetes

K Hemminki, X Li, J Sundquist, K Sundquist - The Oncologist, 2010 - academic.oup.com
Objectives. Cancer and type 2 diabetes (T2D) are two common diseases that may share risk
factors. We aimed at determining subsequent cancer risks in patients hospitalized for T2D in …

Familial risks for type 2 diabetes in Sweden

K Hemminki, X Li, K Sundquist, J Sundquist - Diabetes care, 2010 - Am Diabetes Assoc
OBJECTIVE Our aim was to characterize familial risks for type 2 diabetes by the type and
number of affected family members, including half-siblings, adoptees, and spouses, to …

Systematic review: family history in risk assessment for common diseases

BJ Wilson, N Qureshi, P Santaguida, J Little… - Annals of Internal …, 2009 - acpjournals.org
Background: The usefulness of routinely examining family history in primary care practice is
uncertain. Purpose: To assess the beneficial and adverse effects of collecting family history …

Heterogeneity of patients with latent autoimmune diabetes in adults: linkage to autoimmunity is apparent only in those with perceived need for insulin treatment: results …

MA Radtke, K Midthjell, TIL Nilsen, V Grill - Diabetes Care, 2009 - Am Diabetes Assoc
OBJECTIVE—Subjects with the diagnosis of latent autoimmune diabetes in adults (LADA)
are more prone to need insulin treatment than those with type 2 diabetes. However, not all …

Latent autoimmune diabetes in the adults (LADA) in Asia: from pathogenesis and epidemiology to therapy

C Guglielmi, A Palermo… - … /metabolism research and …, 2012 - Wiley Online Library
Diabetes mellitus is a metabolic disorder resulting from a defect in insulin secretion, insulin
action or both. An effect of this process is chronic hyperglycaemia with disorder of …

Genetic heterogeneity in latent autoimmune diabetes is linked to various degrees of autoimmune activity: results from the Nord-Trøndelag Health Study

E Pettersen, F Skorpen, K Kvaløy, K Midthjell, V Grill - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE Previous studies have indicated that the latent autoimmune diabetes in adults
(LADA) phenotype is heterogeneous and that LADA patients share features of type 1 and …

Presence of anti-GAD in a non-diabetic population of adults; time dynamics and clinical influence: results from the HUNT study

EP Sørgjerd, PM Thorsby, PA Torjesen… - BMJ Open Diabetes …, 2015 - drc.bmj.com
Background It is well known that anti-GAD (glutamic acid decarboxylase) serves as a marker
for development of autoimmune diabetes in adults. On the other hand, the clinical …

Latent autoimmune diabetes in adults: a focus on β-cell protection and therapy

W Yin, S Luo, Z Xiao, Z Zhang, B Liu… - Frontiers in …, 2022 - frontiersin.org
Latent autoimmune diabetes in adults (LADA) is a heterogeneous disease sharing some
phenotypic, genetic, and immunological features with both type 1 and 2 diabetes. Patients …