Potassium is the most abundant cation in the intracellular fluid, and maintaining the proper
distribution of potassium across the cell membrane is critical for normal cell function. Long …

Hyperkalemia is a potentially life-threatening electrolyte disorder appreciated with greater
frequency in patients with renal disease, heart failure, and with use of certain medications …

An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …

Ca2+-and voltage-gated K+ channels of large conductance (BK channels) are expressed in
a diverse variety of both excitable and inexcitable cells, with functional properties …

The aldosterone-sensitive distal nephron (ASDN) includes the late distal convoluted tubule
2, the connecting tubule (CNT) and the collecting duct. The appropriate regulation of sodium …

The kidney is a remarkable organ that accomplishes the challenge of removing waste from
the body and simultaneously regulating electrolyte and water balance. Pro-urine flows …

More than two dozen types of potassium channels, with different biophysical and regulatory
properties, are expressed in the kidney, influencing renal function in many important ways …

The central goal of this overview article is to summarize recent findings in renal epithelial
transport, focusing chiefly on the connecting tubule (CNT) and the cortical collecting duct …

The potassium homeostatic system is very tightly regulated. Recent studies have shed light
on the sensing and molecular mechanisms responsible for this tight control. In addition to …

Aldosterone exerts profound effects on renal and cardiovascular physiology. In the kidney,
aldosterone acts to preserve electrolyte and acid-base balance in response to changes in …