The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

Metabolism and mRNA translation represent critical steps involved in modulating gene
expression and cellular physiology. Being the most energy-consuming process in the cell …

Analyses of gene expression of subsurface bacteria and archaea provide insights into their
physiological adaptations to in situ subsurface conditions. We examined patterns of …

Living systems are built from a small subset of the atomic elements, including the bulk
macronutrients (C, H, N, O, P, S) and ions (Mg, K, Na, Ca) together with a small but variable …

Plasmodium falciparum artemisinin (ART) resistance is driven by mutations in kelch-like
protein 13 (PfK13). Quiescence, a key aspect of resistance, may also be regulated by a yet …

Legume crops provide significant nutrition to humans as a source of protein, omega-3 fatty
acids as well as specific macro and micronutrients. Additionally, legumes improve the …

The eukaryotic multisubunit Elongator complex has been shown to perform multiple
functions in transcriptional elongation, histone acetylation and tRNA modification. However …

Cells must be able to respond and adapt to different stress conditions to maintain normal
function. A common response to stress is the global inhibition of protein synthesis. Protein …

The success of bacterial pathogens depends on the coordinated expression of virulence
determinants. Regulatory circuits that drive pathogenesis are complex, multilayered, and …

The hematopoietic system is highly sensitive to perturbations in the translational machinery,
of which an emerging level of regulation lies in the epitranscriptomic modification of transfer …