Metabolic Regulation of Copper Toxicity during Marine Mussel Embryogenesis

T Young, SL Gale, NLC Ragg, SG Sander, DJ Burritt… - Metabolites, 2023 - mdpi.com
The development of new tools for assessing the health of cultured shellfish larvae is crucial
for aquaculture industries to develop and refine hatchery methodologies. We established a …

Mitochondrial defects associated with β-alanine toxicity: relevance to hyper-beta-alaninemia

A Shetewy, K Shimada-Takaura, D Warner… - Molecular and cellular …, 2016 - Springer
Hyper-beta-alaninemia is a rare metabolic condition that results in elevated plasma and
urinary β-alanine levels and is characterized by neurotoxicity, hypotonia, and respiratory …

Regulatory mechanisms of amino acids in ferroptosis

H Yao, W Jiang, X Liao, D Wang, H Zhu - Life Sciences, 2024 - Elsevier
Ferroptosis, an iron-dependent non-apoptotic regulated cell death process, is associated
with the pathogenesis of various diseases. Amino acids, which are indispensable substrates …

GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine and carnosine production

E Mahootchi, S Cannon Homaei, R Kleppe, I Winge… - Science …, 2020 - science.org
Carnosine and related β-alanine–containing peptides are believed to be important
antioxidants, pH buffers, and neuromodulators. However, their biosynthetic routes and …

L-carnitine prevents oxidative stress in the brains of rats subjected to a chemically induced chronic model of MSUD

CP Mescka, AP Rosa, G Schirmbeck, TH Da Rosa… - Molecular …, 2016 - Springer
Maple syrup urine disease (MSUD), or branched-chain α-keto aciduria, is an inherited
disorder that is caused by a deficiency in branched-chain α-keto acid dehydrogenase …

Phenylalanine induces oxidative stress and decreases the viability of rat astrocytes: possible relevance for the pathophysiology of neurodegeneration in …

T Preissler, IJ Bristot, BML Costa, EK Fernandes… - Metabolic brain …, 2016 - Springer
The aim of this study was to investigate the effects of phenylalanine on oxidative stress and
some metabolic parameters in astrocyte cultures from newborn Wistar rats. Astrocytes were …

Taurine and its transporter TAUT positively affect male reproduction and early embryo development

H Wu, X Zhang, J Yang, T Feng, Y Chen… - Human …, 2022 - academic.oup.com
STUDY QUESTION Are taurine and its transporter TAUT associated with spermiogenesis
and early embryo development? SUMMARY ANSWER Morphologically abnormal …

Effect of arginine supplementation on the morphology and function of intestinal epithelia and serum concentrations of amino acids in pigs exposed to heat stress

A Morales, F González, H Bernal… - Journal of Animal …, 2021 - academic.oup.com
The exposure of pigs to heat stress (HS) appears to damage their intestinal epithelia,
affecting the absorption of amino acids (AA s). Arg is involved in the restoration of intestinal …

[PDF][PDF] Perinatal hypoxia: different effects of the inhibitors of GABA transporters GAT1 and GAT3 on the initial velocity of [3H] GABA uptake by cortical, hippocampal …

N Pozdnyakova, M Dudarenko, L Yatsenko… - Croatian Medical …, 2014 - hrcak.srce.hr
Methods Animals were divided into two groups: control (n= 17) and hypoxia (n= 12). Rats in
the hypoxia group underwent hypoxia and seizures (airtight chamber, 4% O2 and 96% N2) …

Chronic exposure to β-alanine generates oxidative stress and alters energy metabolism in cerebral cortex and cerebellum of Wistar rats

T Gemelli, RB de Andrade, DB Rojas, Â Zanatta… - Molecular …, 2018 - Springer
Abstract β-Alanine occurs naturally in the human central nervous system and performs
different functions. It can act as either a neurotransmitter or a neuromodulator, depletion of …