Substance P (SP) is an undecapeptide present in the CNS and the peripheral nervous
system. SP released from the peripheral nerves exerts its biological and immunological …

The G protein–coupled receptor (GPCR), neurokinin‐1 receptor (NK1R), and its preferred
ligand, substance P (SP), are reviewed in relationship to the immune system and selected …

The inflammatory responses of resident central nervous system (CNS) cells are now known
to play a critical role in the initiation and progression of an array of infectious and sterile …

Respiratory syncytial virus (RSV) is recognized as the most important cause of serious lower
respiratory tract illness in infants and young children worldwide causing repeat infections …

Herpes simplex virus type 1 (HSV-1) travels by retrograde transport to sensory ganglia
where latency is established. Recurrent disease results from virus reactivation and …

Staphylococcus aureus infections of bone tissue are associated with inflammatory bone
loss. Resident bone cells, including osteoblasts and osteoclasts, can perceive S. aureus and …

Although glial cells are recognized for their roles in maintaining neuronal function, there is
growing appreciation of the ability of resident CNS cells to initiate and/or augment …

Substance P (SP) and its natural analogue hemokinin‐1 (HK1) are produced by
lymphocytes and macrophages, and at times B cells. These peptides are an important …

[Frontiers in Bioscience 9, 2153-2165, September 1, 2004] 2153 THE ROLE OF
TACHYKININS IN CENTRAL NERVOUS SYSTEM INFLAMMATORY RE Page 1 [Frontiers …

Viral infections have long been suspected to play a role in the pathogenesis of multiple
sclerosis. In the present study, two different rodent models of experimental autoimmune …