We review the molecular pathogenesis of lung cancer including alterations in dominant
oncogenes, recessive oncogenes/tumor suppressor genes, alterations in growth regulatory …

Publisher Summary This chapter discusses the methodological advantages and limitations
of the various approaches used to localize tumor suppressor genes on 3p, the short arm of …

We used overlapping and nested homozygous deletions, contig building, genomic
sequencing, and physical and transcript mapping to further define a∼ 630-kb lung cancer …

Loss of heterozygosity (LOH) studies have suggested that somatic mutations of a tumour
suppressor gene or genes on chromosome 3p are a critical event In the pathogenesls of non …

Loss of heterozygosity of the small arm of chromosome 3 is one of the most common
alterations in human cancer. Most notably, a segment in 3p21. 3 is frequently lost in lung …

Background.—Deletions in the short arm of chromosome 3 (3p) are present in most lung
carcinomas. Objective.—To investigate the role of these chromosome 3p deletions in the …

Lung cancer is the largest cancer killer of men and women in the united states. In addition to
the progress made from antismoking primary prevention measures, new tools to help treat …

Loss of heterozygosity at 3p21. 3 occurs in more than 90% of small cell lung carcinomas
(SCLCs). The Ras association domain family 1 (RASSF1) gene cloned from the lung tumor …

The Ras GTPases are a superfamily of molecular switches that regulate cellular proliferation
and apoptosis in response to extra-cellular signals. The regulation of these pathways …

Murine MyD88, an RNA with homology both to the interleukin-1 receptor signaling domain
and todeath-domains', is rapidly upregulated during differentiation of the myeloleukemic cell …