Physical access to DNA is a highly dynamic property of chromatin that plays an essential
role in establishing and maintaining cellular identity. The organization of accessible …

Chromatin accessibility, or the physical access to chromatinized DNA, is a widely studied
characteristic of the eukaryotic genome. As active regulatory DNA elements are generally …

The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) disease (COVID-19)
pandemic has caused millions of deaths worldwide. Genome-wide association studies …

Abstract Transposase-Accessible Chromatin followed by sequencing (ATAC-seq) is a
simple protocol for detection of open chromatin. Computational footprinting, the search for …

Predicting the impact of noncoding genetic variation requires interpreting it in the context of
three-dimensional genome architecture. We have developed deepC, a transfer-learning …

Super-enhancers are compound regulatory elements that control expression of key cell
identity genes. They recruit high levels of tissue-specific transcription factors and co …

Background The incidence of pulmonary embolism complications in the literature ranges
from 10 to 50%, with a 0.5–10% risk of fatal pulmonary embolism. However, the biological …

The recent accumulation of cancer genomic data provides an opportunity to understand how
a tumor's genomic characteristics can affect its responses to drugs. This field, called …

Super-enhancers (SEs) are a class of compound regulatory elements which control
expression of key cell-identity genes. It remains unclear whether they are simply clusters of …

Accessible chromatin is a highly informative structural feature for identifying regulatory
elements, which provides a large amount of information about transcriptional activity and …