A global review on short peptides: frontiers and perspectives

V Apostolopoulos, J Bojarska, TT Chai, S Elnagdy… - Molecules, 2021 - mdpi.com
Peptides are fragments of proteins that carry out biological functions. They act as signaling
entities via all domains of life and interfere with protein-protein interactions, which are …

Multiple sclerosis: immunopathology and treatment update

N Dargahi, M Katsara, T Tselios, ME Androutsou… - Brain sciences, 2017 - mdpi.com
The treatment of multiple sclerosis (MS) has changed over the last 20 years. All
immunotherapeutic drugs target relapsing remitting MS (RRMS) and it still remains a …

Peptide-drug conjugates: a new hope for cancer management

VP Chavda, HK Solanki, M Davidson… - Molecules, 2022 - mdpi.com
Cancer remains the leading cause of death worldwide despite advances in treatment
options for patients. As such, safe and effective therapeutics are required. Short peptides …

Targeting antigens to dendritic cell receptors for vaccine development

V Apostolopoulos, T Thalhammer… - Journal of drug …, 2013 - Wiley Online Library
Dendritic cells (DCs) are highly specialized antigen presenting cells of the immune system
which play a key role in regulating immune responses. Depending on the method of antigen …

Review cyclic peptides on a merry‐go‐round; towards drug design

A Tapeinou, MT Matsoukas, C Simal… - Peptide Science, 2015 - Wiley Online Library
Peptides and proteins are attractive initial leads for the rational design of bioactive
molecules. Several natural cyclic peptides have recently emerged as templates for drug …

Streptococcusthermophilus ST285 Alters Pro-Inflammatory to Anti-Inflammatory Cytokine Secretion against Multiple Sclerosis Peptide in Mice

N Dargahi, J Matsoukas, V Apostolopoulos - Brain sciences, 2020 - mdpi.com
Probiotic bacteria have beneficial effects to the development and maintenance of a healthy
microflora that subsequently has health benefits to humans. Some of the health benefits …

Small Extracellular Vesicles Derived from Altered Peptide Ligand‐Loaded Dendritic Cell Act as A Therapeutic Vaccine for Spinal Cord Injury Through Eliciting CD4+ …

S Wang, G Li, X Liang, Z Wu, C Chen… - Advanced …, 2024 - Wiley Online Library
The balance among different CD4+ T cell subsets is crucial for repairing the injured spinal
cord. Dendritic cell (DC)‐derived small extracellular vesicles (DsEVs) effectively activate T …

[HTML][HTML] Liposome-encapsulated peptides protect against experimental allergic encephalitis

AA Belogurov Jr, AV Stepanov, IV Smirnov… - The FASEB …, 2013 - ncbi.nlm.nih.gov
Multiple sclerosis (MS) is a severe inflammatory and neurodegenerative disease with an
autoimmune background. Despite the variety of therapeutics available against MS, the …

Systemic immunization with altered myelin basic protein peptide produces sustained antidepressant-like effects

Y Han, CY Sun, SQ Meng, S Tabarak, K Yuan… - Molecular …, 2020 - nature.com
Immune dysregulation, specifically of inflammatory processes, has been linked to behavioral
symptoms of depression in both human and rodent studies. Here, we evaluated the …

[HTML][HTML] CD206-targeted liposomal myelin basic protein peptides in patients with multiple sclerosis resistant to first-line disease-modifying therapies: a first-in-human …

A Belogurov Jr, K Zakharov, Y Lomakin, K Surkov… - …, 2016 - Elsevier
Previously, we showed that CD206-targeted liposomal delivery of co-encapsulated
immunodominant myelin basic protein (MBP) sequences MBP 46–62, MBP 124–139 and …