Conventional disease-modifying antirheumatic drugs such as methotrexate are the mainstay
of treatment for rheumatoid arthritis. More recently, biologic agents such as etanercept …

A failure to respond to TNF inhibitors remains a serious concern for patients with RA.
Although some patients experience a primary lack of drug efficacy in reducing their …

Purpose To compare the effectiveness of anti-tumour necrosis factor (TNF) agents in
biologically naive and 'switched'rheumatoid arthritis (RA) patients. Methods RA patients …

Objective: To quantify and compare direct costs, utilization, and the rate of comorbidities in a
sample of patients with fibromyalgia (FM), a poorly understood illness associated with …

Introduction The long-term treatment of rheumatoid arthritis (RA) most often involves a
sequence of different therapies. The response to therapy, disease progression and detailed …

Introduction To examine treatment persistence and clinical outcomes associated with
switching from a tumor necrosis factor inhibitor (TNFi) to a medication with a new …

OBJECTIVE: To investigate resource consumption and quality of life (utility) in a sample of
patients covering the full spectrum of the disease, modalities of patient management and …

Introduction After a patient with rheumatoid arthritis (RA) fails tumor necrosis factor inhibitor
(TNFi) treatment, clinical guidelines support either cycling to another TNFi or switching to a …

Objective. Patients with rheumatoid arthritis (RA) commonly switch between tumor necrosis
factor (TNF) inhibitors after failing to control disease activity. Much of the clinical data that …

Background Step-up therapy is a patient management approach that aims to balance the
efficacy, costs and risks posed by different lines of medications. While the initiation of first …